Connect with us

International

International cooperation provides 1 million grant to investigate new lymphoma treatment target

Published

on

 


An international collaboration involving researchers from Queen Mary University of London, Memorial Sloan Kettering Cancer Center (MSK), New York and the Dana-Farber Cancer Institute, Boston has secured a $ 1 million research grant from the Dutch Blood Cancer Charitable Association. Lymph & Co., to investigate a new treatment. target for lymphoma.

The aim of the project is to determine how the target of a protein called KDM5 kills lymphoma cells and to identify the groups of patients who are most likely to benefit from this type of treatment.

Lymphoma is a type of blood cancer that arises from white blood cells called lymphocytes. Changes in the genetic code (mutations) of lymphocytes can cause them to grow uncontrollably and, as a result, these white blood cells accumulate in the lymph nodes and other tissues, eventually causing lymphoma. There are two main types of lymphoma: Hodgkin’s lymphoma and non-Hodgkin’s lymphoma (NHL), which include over 60 subtypes.

Fighting the effects of common lymphoma mutations

Research has shown that many lymphoma patients have one or more mutations in a gene called KMT2D. The KMT2D gene encodes a protein involved in controlling gene expression within cells; however, mutations that inhibit the proper functioning of KMT2D (leading to changes in the expression of genes necessary for normal cell function) are the most common mutations detected in lymphoma.

Collaborative teams, led by Professors Jude Fitzgibbon at the Queen Mary’s Barts Cancer Institute (BCI), Hans-Guido Wendel, MD at MSK, and David Weinstock, MD at Dana-Farber, are leaders in the study of lymphomas using cell lines and animal patterns. . Based on recent experiments, researchers believe that the target of a protein – called KDM5 – that normally counteracts the effects of KMT2D could alter the effects of KMT2D mutations on lymphomas, causing lymphoma cell death.

The project will build on previous work by teams, including recent research led by BCI professor Fitzgibbon and former postdoctoral researcher Dr. James Heward, who discovered the inhibition of KDM5 to reverse the effects of KMT2D mutations on cell lines and preclinical patterns of an NHL group. called germinal center lymphomas. It is also based on previous work by the Wendel laboratory that first characterized the role of KMT2D mutations in the development of lymphoma.

Lead researcher from BCI, Professor Fitzgibbon, said: “Thanks to the generous support of Lymph & Co., we have the opportunity to build a unique international collaboration, to build on our groups’ understanding of KMT2D mutations and to determine if the inhibitory power of KDM5 is specific for germ center lymphomas or may have a wider therapeutic potential in other non-Hodgkin lymphomas. “

A precise-medical approach

Much research has focused on what distinguishes one type of lymphoma from another. KMT2D mutations are present in only 5-20% of some lymphoma subtypes, but up to 80% of a lymphoma subtype called follicular lymphoma, which is the second most common lymphoma in the UK, US and Europe. Therefore, teams will investigate whether the goal of KDM5 can be an effective therapeutic approach for a range of lymphoma subtypes. Indeed, KMT2D and related genes have been mutated into many other cancers, so an effective therapeutic target of KDM5 may be widely beneficial to many people with cancer.

If research shows that KDM5-led therapy is effective in compensating for the effects of KMT2D mutations on lymphoma, then the study could provide a new approach to treating lymphoma. As part of the project, the researchers aim to identify KDM5 inhibitors that would be suitable for evaluation as part of early-stage clinical trials and to create populations of patients who are most likely to benefit from these therapies.

Furthermore, by improving their understanding of the harmful effects of KMT2D mutations within lymphocytes, the team seeks to identify other molecules that can be targeted with drugs already approved for clinical use.

Dr. Weinstock, who heads the Lavine family for cancer prevention therapies at Dana-Farber and is a professor of medicine at Harvard Medical School, said: “It is a great honor to be part of this team under the leadership of Dr. Fitzgibbon. “Our goal is to utilize the talent and resources in our research programs to directly target one of the most important changes in follicular lymphoma and other cancers.”

“This is a great time to translate the understanding of cancer mechanisms into new lymphoma therapies.”

Dr. Wendel, Professor, Cancer Biology and Genetics Program, MSK

Prof. Dr. Bob Lowenberg, chairman of the scientific advisory board of Lymph & Co., said: “The aim of Lymph & Co. is to provide leading doctors and scientists researching lymph node cancer with tools that allow them to carry out this research anywhere in the world. Within this unique research project Lymph & Co, an international consortium of top researchers from London, Boston and New York will join forces and have the opportunity to seek better treatment options for patients with common forms of lymph node cancer. these researchers. “

Sources

1/ https://Google.com/

2/ https://www.news-medical.net/news/20211125/International-collaboration-secures-e282ac1M-grant-to-investigate-new-treatment-target-for-lymphoma.aspx

The mention sources can contact us to remove/changing this article

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

ExBUlletin

to request, modification Contact us at Here or [email protected]