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International Therapeutic Solutions Announces StemVacs-V iPSC Immunotherapeutic Cancer Immunological Action Mechanism




CITY ELK, Idaho, March 22, 2021 / PRNewswire / –Therapeutic Solutions International, Inc., (OTC Markets: TSOI), today announced new data demonstrating its StemVacs-V iPSC-derived dendritic cell product stimulates two distinct immune mechanisms responsible for the activity of his anticancer in animal studies.

In a series of experiments, Company scientists noticed that mice carrying B16 melanoma treated with StemVacs-V had an increased T cell response to the tumor-related antigen Brother of the Regulator of Imprinted Sites. Furthermore, examination of tumors that regress as a result of StemVacs-V treatment revealed increased infection of macrophages and natural killer cells. Reduction of T cells or natural killer cells in treated rats abolished the cancer-reducing activity of StemVacs-V.

“As we advance our flow-derived product toward FDA registration, it is important to demonstrate not only reproducible efficiency but also specific mechanisms of action,” said Dr. James Veltmeyer, Chief Medical Officer of International Therapeutic Solutions. “We are particularly excited about the dual mechanism of action displayed by StemVacs-V, suggesting potential advantages over other cancer therapies which usually only stimulate adaptive or innate immunity.”

“Although current immunotherapies such as checkpoint inhibitors have resulted in remission in many types of advanced cancer, these approaches still fail to produce a meaningful response in tumors considered immunologically ‘cold,'” he said. Famela Ramos, Vice President of Business Development for the Company. “Given that tumors that respond to checkpoint inhibitors are typically characterized by natural killer cell infiltration, we are currently considering the use of StemVacs-V as an alarm for other FDA-approved immunotherapies.”

“We are extremely excited about the rapid pace that our team is advancing the StemVacs-V product, which promises to be a type of immunotherapy that is: a) easy to produce in large quantities; b) can be adapted with different biological characteristics cancers and c) seems safe and very powerful in existing animal studies “, said Timothy Dixon, President and CEO of the Company.

About Therapeutic Solutions International, Inc.
Solutions Therapy International is focused on immune modulation for the treatment of some specific diseases. The Company’s corporate website is, and our public forum is

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SOURCE International Therapeutic Solutions

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