Connect with us

Health

Researchers Find Biological Linkage Between Lean Meat and Colorectal Cancer

Published

on

 


Issuance: Change:

Washington (AFP)

Eating less lean meat is standard medical advice for preventing colorectal cancer, but it is unclear how it mutates cells and all experts are convinced that it is strongly associated. Not at all.

A new paper in the journal Cancer Discovery identified specific patterns of DNA damage caused by a lean meat-rich diet. In addition, it suggests food as a carcinogen, telling us the possibility of detecting cancer early and designing new treatments.

Studies prior to establishing relationships were primarily epidemiological. That is, people who developed this condition were investigated for their diet, and researchers found an association with the incidence of colorectal cancer.

However, the lack of biology clarity means that the incident was not entirely slam dunk, and in 2019, one team of researchers said that reducing consumption was “low” to prevent cancer deaths. I made a wave when I declared that I was only convinced.

“When we say that lean meat is carcinogenic and affects the incidence of cancer, we need a plausible way to do it,” said an oncologist at the Dana Farber Cancer Institute, who led the new study. , Marios Jannakis told AFP.

After all, scientists long ago wondered which chemicals in cigarette smoke are responsible for cancer, and how certain bands of UV light penetrate the skin, causing cell growth and division. We have discovered that it causes mutations in the controlling genes.

To address the knowledge gap, Giannakis and his colleagues found 900 people with colorectal cancer extracted from a much larger group of 280,000 healthcare professionals who participated in many years of research, including lifestyle studies. DNA data from the patient was sequenced.

-Detective work-

The strength of this approach is that there was no way for people recording their diet to know their future cancer diagnosis, rather than asking them to remember their diet after getting sick.

The analysis revealed clear signs of mutation. This is a pattern that has never been identified, but it has shown a type of DNA damage called “alkylation.”

Not all cells containing these mutations became cancerous, and some healthy colon samples were also characterized.

Signs of mutation were significantly associated with both processed and raw lean meat intake before the patient was diagnosed with cancer, but tested poultry, fish, or other lifestyle factors. It was not related to the intake of.

“There are chemicals in lean meat that can cause alkylation,” Giannakis explained.

Certain compounds are nitroso compounds that can be made from heme, which is abundant in lean meats, and nitrates, which are common in processed meats.

Mutation patterns are strongly associated with the distal colon, the lower part of the intestine that connects to the anal canal, and previous studies have suggested that colon cancer associated with lean meat predominantly occurs.

In addition, among the genes most affected by the alkylation pattern, previous studies have shown that they are one of the most common drivers of colorectal cancer when mutated.

Overall, multiple lines of evidence build a compelling argument, Giannakis said, comparing the study to the work of a careful detective.

-Promoted moderation-

In this case, there are many answers to the signs of suspicious mutation. Patients with the highest level of tumor alkylation damage had a 47% higher risk of colorectal cancer-specific mortality compared to patients with lower levels of damage.

But also practitioner Jannakis said it was important to focus on how the study could be used to help patients.

Future studies may help physicians identify which patients have a genetic predisposition to accumulate alkylation damage and advise them to limit lean meat intake.

Identifying patients who are already beginning to show signs of mutation can help identify those who are at high risk of developing cancer or detect the disease earlier.

Also, the amount of alkylation damage appears to be a biomarker of patient survival and could be used to inform patients of prognosis.

Finally, understanding the biological pathways by which colorectal cancer develops paves the way for drugs that disrupt or reverse the process and prevent the disease.

Janakis emphasized that the take-out message does not mean that people should not completely refrain from lean meat. “My recommendation is that a modest and balanced diet is important.”

High levels of tumor alkylation damage were found only in patients who ate an average of 150 grams (5 ounces) or more per day. This is roughly equivalent to two or more servings.

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos



Pictures Credit

ExBUlletin

to request, modification Contact us at Here or [email protected]