Health
New study seeks to determine COVID-19 incidence in children
As of April 27, JAMA Pediatrics We recommended the need for future epidemiologic and clinical studies to identify possible prophylactic and therapeutic strategies for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in pediatric patients.2
The human epidemiology and response of the SARS-CoV-2 (HEROS) study will help determine what percentage of SARS-CoV-2 infected children develop COVID-19 symptoms. In addition, the HEROS study will investigate investigators to determine whether SARS-CoV-2 infection rates differ between children who have asthma or other allergies and those who do not.1
The HEROS research team will enroll 6000 people in 2000 families who are already participating in a NIH-funded pediatric study in 11 cities. Healthy children and children with asthma and other allergic conditions can participate.1
The research team followed the child and his family for 6 months to find out who was infected with SARS-CoV-2, whether the virus had infected other families, and members of the virus-infected family developed COVID-19. Determine if you did.1
A previous study recently examined the expression of upper and lower airway cells ACE2A gene encoding a receptor that COVID-19 uses to infect cells. Expression of ACE2 According to the press release, those with high levels of asthma and those sensitive to allergens had the lowest levels.1
HEROS studies help clarify if there is a decrease ACE2 Gene expression in airway cells of children with allergic disease correlates with lower rates of SARS-CoV-2 infection and COVID-19.1
The study is conducted remotely and caregivers of the participating family members collect nasal swabs every two weeks from their primary study participant, a child, and all other registered families. Samples will be mailed to the lab for analysis.1
In addition, caregivers will complete a questionnaire about each participant’s current symptoms, social distance practices, recent activities outside the home, and recent contact with sick people.1
If a member of the household develops symptoms of a viral illness during the survey, the caregiver will complete another online questionnaire designed to determine that the illness may be COVID-19. If COVID-19 is likely, caregivers will collect nasal swabs from all study participants and stool samples from symptomatic participants within 24 hours.1
A laboratory analysis of nasal swabs tests SARS-CoV-2 and evaluates gene expression in collected airway surface cells. The team hopes that gene expression studies will reveal patterns that correlate with higher and lower risk of infection, the development of COVID-19 symptoms, and SARS-CoV-2 infection.1
Blood samples will also be collected from each study participant every 2, 18, or 24 weeks after enrollment by the caregiver and, if applicable, after the first likely COVID-19 case in the family. Blood is collected using a new device and a small amount is extracted from the surface of the skin. Blood is then analyzed for antibodies to SARS-CoV-2 when appropriate antibody tests are available.1
reference
- Studies begin to determine the incidence of new coronavirus infections in US children. NIH (National Institute of Health) (# If there is no character limit, add brackets when first appearing. https://www.nih.gov/news-events/news-releases/study-determine-incidence-novel-coronavirus-infection-us-children-begins. Published on May 4, 2020. Accessed May 4, 2020.
- Murphy, Jill. Lack of data on SARS-CoV-2 pediatric patients, further epidemiologic studies needed. Modern clinic. https://contemporaryclinic.pharmacytimes.com/news-views/lack-of-data-on-pediatric-patients-with-sars-cov-2-further-epidemiologic-studies-required. Published April 27, 2020. Accessed May 4, 2020.
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