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Symbiotic bacteria in the human intestine produce compounds that inhibit SARS-CoV-2




Researchers at Yonsei University in South Korea have discovered that certain symbiotic bacteria in the human intestine produce compounds that inhibit SARS-CoV-2.

The study will be conducted on June 20th at the World Microbial Forum, the American Society for Microbiology (ASM), the European Association of Microbiology (FEMS), and online conferences of several other academic societies online June 20-24. Will be announced at.

Previous clinical findings have shown that some patients with moderate to severe COVID-19 have gastrointestinal symptoms and others have signs of infection only in the lungs.

“I was wondering if gut bacteria could protect the gut from the invasion of the virus,” said PhD Mohammed Ali. A medical student at Yonsei University in Seoul, South Korea.

To investigate this hypothesis, researchers screened the predominant gut-dwelling bacteria for their activity against SARS-CoV-2. According to their investigation, H. Bifidobacterium, which has previously been shown to suppress other bacteria such as pylori and has been shown to be active against irritable bowel syndrome, has been shown to have such activity, Said Ali.

Researchers also use machine learning to search databases containing molecules produced by microorganisms for compounds that fight potential diseases and prove to be useful against SARS-CoV-2 as well. I found something that could be possible.

We leveraged our previous coronavirus dataset to train our models.In this dataset, some compounds Coronavirus.. This approach seems important because these targets share common functionality with SARS-CoV-2... “

Muhammad Ali, Ph.D. in Medicine, Yonsei University

Ali emphasizes the ecological nature of his approach to this study, and many existing antibiotics and cancer treatments are compounds that bacteria use to compete with each other in the gastrointestinal tract, and these are the first We observed that it was purified from microbial secretions.

“Finding microorganisms that secrete anti-coronavirus molecules develops natural or artificial probiotics to extend our therapeutic and preventive techniques to provide a more sustainable way to combat viral infections. It will be a promising way to do it, “said Ali.


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