Health
The drug “does not affect cognitive decline in people with Alzheimer’s disease”
New studies suggest that drugs to prevent Alzheimer’s disease do not significantly affect cognitive decline.
However, treatment reduced disease markers and suppressed neurodegeneration in the brain.
These results led researchers to provide participants with a drug known as gantenumab as part of an exploratory study.
the scientist We continue to monitor changes in Alzheimer’s disease readings in participants taking the drug.
The ability of the drug to successfully shift multiple Alzheimer’s disease biomarkers indicates that it has a positive impact on the disease process.
The DIAN-TU study evaluated the effects of two investigational drugs, gantenumab. Roche Genentech and Solanezumab, US affiliates manufactured by Eli Lilly and Company, target people with rare, hereditary early-onset Alzheimer’s disease.
It is known as dominantly inherited Alzheimer’s disease (DIAD) or autosomal dominant Alzheimer’s disease.
Man This form of illness is born with mutations that cause Alzheimer’s disease and experiences memory and thinking loss in the 30s or 40s.
DIAD is estimated to account for less than 1% of cases.
Randall Bateman, Principal Investigator, Director of DIAN-TU, and prominent neurology professors at the University of Washington, Charles F and Joanne Knight, said: “Gantenerumab has had a significant impact on the biomarkers of Alzheimer’s disease.
“The ability of the drug to successfully shift multiple Alzheimer’s disease biomarkers indicates that it has a positive impact on the disease process.
“The effect was strong enough that we started an open-label extension of the trial, so participants have the opportunity to stay on the drug while we continue to study it.”
In this study, 144 DIADs received either gantenerumab or solanezumab or a placebo control for up to 7 years.
The drug did not prevent or delay cognitive decline in people who were almost certain to develop Alzheimer’s disease due to genetic variation.
The researchers showed little or no decline in cognitive function and were unable to determine the effects on thinking and memory of participants who participated in the study without symptoms.
The study also evaluated the effect of the drug on the molecular and cellular signs of Alzheimer’s disease.
Gantenerumab has shown potential benefits in these measures, according to a study published in Nature Medicine.
“While this trial focuses on people with rare mutations, successful drugs in this population are promising candidates for preventing or treating the more common forms of Alzheimer’s disease in the elderly. “It will be,” said Dr. Bateman.
“Destructive molecular and cellular processes in the brain are similar in both types of disease.”
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