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Pune studies suggest effective measles vaccination against SARS-CoV-2.Pune news




Pune: A study by researchers at BJ Medical College here found early evidence that a measles-containing vaccine (MCV) may provide some protection for children. SARS-CoV-2 infection.

The case-control study analyzed 548 participants aged 1 to 17 years. These participants were divided into two groups. RT-PCR) And those who aren’t. Researchers found that MCV had 87.5% vaccine efficacy against SARS-CoV-2, and vaccinated participants showed less severe Covid symptoms than unvaccinated participants. I found that.

Pune’s findings often argue that children are significantly protected from SARS-CoV-2 due to “non-specific immunity” after vaccination with live attenuated vaccines, including MCV and bacillus Calmette gellan (BCG) shots. Supports the hypothesis that has been made. The measles vaccine has been part of India’s universal vaccination program for the past 36 years.
BJ Medical College’s research was published this month in the peer-reviewed international journal Human Vaccines and Immunotherapeutics.
Researchers said their findings are promising, but larger trials are needed before they can draw definitive conclusions about the protection provided by MCV against SARS-CoV-2 infection. ..
“The results of our study show that MCV may be effective against SARS-CoV-2 infection in the pediatric population, but this finding is further enhanced through prospective, randomized clinical trials. We need to make sure, “said Nilesh Gujar, a pediatrician who is the principal investigator of the study.
In India, the measles vaccine is given every 9 and 15 months. In 2018, the federal government launched a measles-rubella eradication campaign for children under the age of 18 who had not been vaccinated at these ages. Children enrolled in the Pune study recorded evidence of vaccination.
The effects of SARS-CoV-2 have less effect on the pediatric population than in adults. However, experts said children can be important promoters of the virus’s transmission. the current, Pfizer The vaccine against SARS-CoV-2 (not yet available in the country) is approved for children (ages 12-15). In India, tests are being conducted to find suitable shots for children.
“A case-control study evaluated the effectiveness of MCV in preventing SARS-CoV-2 infection and reducing its severity,” said community medicine, one of the dean and researchers at BJ Medical College and Susoon Hospital. Expert Muralidhar Tambe said.
According to available data, between 2019 and 2020, the national coverage of the initial MCV dose ranged from 72.5% to 96.2%. The second dose range ranged from 11.7% to 44.4%.
The researchers said their study evaluated the efficacy of MCV against SARS-CoV-2, not its effectiveness.
“Efficacy is the extent to which a vaccine prevents disease and, in some cases, infection under ideal and controlled conditions (comparing the vaccinated and placebo groups). Efficacy is. It refers to how well it works in the real world, “said Prasad Kulkarni, a vaccine researcher who is one of the researchers in this study.
Other members of the research team included Malangori Parande, Nandkumar Salunke, Ganesh Jagdale, Sarah Anderson, Abhijeet Dharmadhikari, and Anand Lakhkar.
Infectious disease expert Sanjay Pujari, a member of the Covid-19 National Task Force, said: Such studies add up what we already knew and enhance them. ”


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