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17 million undiagnosed COVID-19 cases in the United States

 


June 24, 2021-5 times the number of reported cases SARS-Early CoV-2 infection Pandemic, NIH researchers suggest if you want to get closer to the true number of infected Americans.

For each infected person reported by mid-July 2020, another 4.8 Americans were undiagnosed, many of whom were mild or asymptomatic. This represents an additional 16.8 million infections, in addition to the officially reported 4.8 million cases.

“During the outbreak of the respiratory virus and the pandemic, the cases identified are often only a small part of what is actually happening in the community,” said lead author Matthew J. Medscape Medical News.

Memoli et al. Used 8,058 dry blood samples to test for antibodies to SARS-CoV-2. Participants were not diagnosed with COVID-19. Each has completed a behavioral risk factor monitoring system study to help researchers study representative samples nationwide.

By studying seropositive, “a better understanding of how quickly the virus could spread and a more accurate estimate of how long it could have occurred in the United States before it was fully recognized. You can, “said the NIH National Institute of Allergy and Infectious Diseases.

The· Research Published online on June 22nd Scientific translation medicine..

George Rutherford, MD, MD, Director of Epidemiology and Biostatistics, Department of Prevention and Public Health, University of California, San Francisco, said: Medscape Medical News..

“This kind of research trying to understand how the virus got into the United States could be useful next time,” adds Rutherford, who is not involved in the study.

Higher rates for women, African Americans

Memoli et al. Were able to estimate differences by geography, age, gender, and race. For example, in the northeastern United States and the Mid-Atlantic, seroprevalence was highest because it was lowest in the Midwest. At the time the blood samples were collected, the seroprevalence in urban areas was 5.3%, compared to 1.1% in rural areas.

The estimated seropositive rate for women was as high as 5.5%, compared to 3.5% for men. On the other hand, African Americans have the highest estimated seroprevalence at 14.2%, followed by other / private racial participants at 11.1%, Native Americans / Alaska Natives at 6.8%, and Caucasians / whites. It was 2.5%. In this study, the lowest estimated serum prevalence in Asians was 2.0%.

Lessons learned

Rutherford said it would be useful to continuously monitor blood donors across the United States for early insight into future pandemics.

In addition to being better prepared, Memoli states that their findings may contribute to more accurate COVID-19 infection and mortality. This kind of information “helps to evaluate the various measures taken to reduce the effects of the pandemic.”

Underreporting of early cases of a pandemic can be partially explained by the lack of early high-quality testing, clear case definitions, and high clinical suspicion, says Memoli.

The current report is part of NIH’s year-round effort to monitor the evolution of SARS-CoV-2 immunity in the United States. Two parts of this study “provide a better understanding of how this pandemic and immunity developed. Both countries before and after the vaccine became available,” says Memoli.

Medscape Medical News

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