New studies may lead to improved decision-making when allocating treatment to children with advanced cancer rhabdomyosarcoma after revealing the important genetic changes that underlie the development of the disease.
In the largest and most comprehensive study of rhabdomyosarcoma to date, scientists find that certain genetic changes in tumors are associated with aggression, early age of onset, and location within the body. Did.
All these factors affect a child’s chances of surviving the disease-and understanding how children are driven by the genetics of cancer is a new coordinating treatment for each patient. It can lead to a way.
Rhabdomyosarcoma is a rare type of cancer that resembles muscle tissue and mainly affects children. Less than 30 percent of children with rhabdomyosarcoma who have relapsed or have spread cancer will survive.
A new international study led by researchers at the London Cancer Institute may help find children with particularly aggressive cancers who require intensive treatment and close monitoring. You can also identify other children who can benefit from less aggressive treatment and escape some of the most serious side effects of treatment.
Researchers are already planning to incorporate new insights into the design of future clinical trials aimed at improving disease management.
An international group of researchers analyzed DNA from 641 patients with rhabdomyosarcoma.This study is today (Thursday) Journal of Clinical Oncology It was also funded by Cancer Research UK and several charities specially funded for the study of rhabdomyosarcoma, Chris Lucas Trust, Talan’s Trust and Alice’s Arc.
There are two major subtypes of rhabdomyosarcoma, depending on the presence of the “fusion gene”: fusion gene positive and fusion gene negative. A fusion gene is a hybrid gene formed from two previously separate genes (in this case, a gene called a PAX gene and a gene called FOXO1).
Looking at children with fusion-negative rhabdomyosarcoma, researchers found that children with tumor defects in the MYOD1 and TP53 genes were significantly less responsive to treatment and had poor survival outcomes. TP53 changed in 69 of 515 children and was associated with worse survival outcomes.
About half of the children who had the TP53 mutation in their cancer died of their illness, compared to one in four children who had the cancer without the TP53 mutation.
Researchers found mutations in MYOD1 in 17 of 515 children and linked them to both worse outcomes and the rapid progression of the disease. Findings suggest that children with these mutations may benefit from more aggressive treatment.
A small number of children with fusion-positive rhabdomyosarcoma (5 of 126) also had changes in TP53. None of these children survived cancer, and as a result, researchers also identified TP53 as a “high-risk” indicator for this subgroup.
Researchers also found that too many copies of the CDK4 or MYCN gene may be associated with poor outcomes of fusion-positive rhabdomyosarcoma, showing these genetic changes in 16 and 13 cases, respectively. I think it is. However, the number of cases in this study was small and needs further investigation in future studies.
New studies challenge the previous finding that the presence of defects in the RAS gene is associated with adverse consequences. However, researchers have found that some RAS mutations appear to correlate with a particular age of onset-HRAS mutations that occur in infants, KRAS mutations in infants, and NRAS in adolescence. Mutation.
Infants have previously been shown to have a lower survival rate than older children. This may be because clinicians avoid using more aggressive treatments such as radiation for the youngest patients. Taking into account the results of this study, researchers believe that the use of targeted drugs such as tipifarnib, which blocks HRAS, may be particularly beneficial to these young, vulnerable, and high-risk patients. I am.
Research leader Janet Shipley, a professor of molecular pathology at the Cancer Institute in London, said:
“Our findings shed light on the underlying genetic changes in rhabdomyosarcoma, a rare and aggressive childhood cancer. By examining the genetic characteristics of different tumors, different children It can be divided into various risk groups and can be used as a guideline for treatment.
“Decades of clinical trials have created the current complex system for assigning risk to children with rhabdomyosarcoma, but the current system is sufficient to properly assign treatment to individual children. It turns out to be inaccurate. Our findings need to improve the current system and the treatments offered by clinicians. Ultimately, further research reveals high levels with specific genetic defects. New drugs may be revealed to coordinate the treatment of patients with risk rhabdomyosarcoma. “
This international collaboration has linked certain genetic changes in cancer to the way children respond to treatment. It should help clinicians treat their children according to the specific characteristics of their cancer and their risk of developing their cancer. The findings are true not only for survival but also for quality of life by not only choosing the children in need of the most aggressive treatment, but also saving other children at low risk from the side effects of intensive intervention. May affect. “”
Professor Paul Workman, Chief Executive Officer, London Cancer Institute
Alice’s arc was inspired by Sarah and David’s daughter Alice, who was diagnosed with rhabdomyosarcoma at the age of three. Alice’s Arc was established shortly after her diagnosis. Alice died four and a half years later at the age of seven. Sara Wakeling, co-founder of Alice’s Arc, said:
“We believe that the future of effective and kind treatment of rhabdomyosarcoma depends on understanding the characteristics of each individual’s tumor and adjusting the treatment accordingly. We are pleased to have played a role in helping to better understand these genetic features and how they work. They are part of the prediction of outcomes and their impact on treatment pathways. With the ICR team. We look forward to working together to uncover the findings of more clinically translatable studies to defeat this devastating childhood cancer. “
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
- 8 cool things to do this summer in Ortigas – Manila Bulletin May 16, 2022
- Finland and Sweden join NATO is not a threat to Russia, but military expansion will trigger a response May 16, 2022
- Rust Producer Says Movie Will Be Over Hollywood Reporter May 16, 2022
- How domestic investors are fueling the resilience of Indian markets May 16, 2022
- Canadians will have their say on how to adapt to climate change May 16, 2022