Health
Scientists have found a way to disable the genes that cause obesity: do you need to worry about being overweight?
Researchers at the University of Washington School of Medicine in St. Louis have disabled genes in certain mouse cells to prevent them from becoming obese after being fed a high-fat diet.
Macrophages, key inflammatory cells involved in the detection, uptake, and destruction of pathogens, were blocked by scientists. Since obesity correlates with chronic mild inflammation, we investigated whether reducing inflammation would help reduce weight gain and obesity.
The study was conducted on April 20, 2020, Journal of clinical research.
According to the lead investigators of the study, Steven L. Teitelbaum, MD, and Professors of Pathology and Immunology of Wilma and Roswell Messing, their study found that they could regulate weight gain by regulating the activity of inflammatory cells. We have developed a proof of concept that is possible.
He added that it may work in several ways, but their team believed it might be able to better control obesity and its complications by managing inflammation. It was
Also read: Research shows that there is a link between obesity and brain function
the study People from Touro College in New York suggest that obese people burn less calories than non-obese people. The same is true for mice.
However, the co-author of the study, Dr. Weizou, MD, associate professor of pathology and immunology, found that obese mice manage the same level of caloric burning as non-obese mice.
This is a team ASXL2 gene Macrophages of obese mice. In the second set of experiments, the same results were obtained after injecting mice with nanoparticles that interfered with gene activity.
Treated mice burned 45% more calories than obese mice with active genes in macrophages, whether fed a high-fat diet or not. Scientists are not sure how it prevented mouse obesity.
Fatty liver disease
According to Titerbaum, Most Americans now have fatty liver Their fat deposits are unable to absorb the fats they consume, and the fats move elsewhere.
The Harvard newsletter is Fatty liver disease It occurs when some of the fat molecules accumulate in hepatocytes. The presence of these enlarged cells can lead to liver inflammation and damage to surrounding liver tissue. Scientists claim that obesity and diabetes epidemics are responsible for the disease.
He added that he never got fatty liver despite the fact that the mice were on a high-fat diet. Teitelbaum believes that limiting the inflammatory effects of macrophages can burn more fat. In return, this keeps the mouse healthier and slimmer.
Another co-author of the study and pathology instructor Nidi Rohage explained that it appears to be related to making white adipocytes behave like brown adipocytes.
White fat cells Store fat that becomes obese Brown fat cells Helps burn stored fat. Although the approach in this study has a long way to go to cure, researchers believe that it may help obese people burn fat at a rate similar to that found in lean people. I am.
Also read: New research reveals that obesity can result from genetics
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