Connect with us


Survey Finds Statistical Relationship Between Heart Failure, Cancer Incidence




A retrospective cohort study matched the age, gender, diabetic status, obesity, and frequency of annual visits to determine the overall and specific types of cancer incidence in 100,124 patients with heart failure and 100,124 without heart failure. I investigated. Diagnosis was made in more than 1000 general practice in Germany between January 2000 and December 2018. The mean (SD) patient age in both groups was 72.6 (12.2) years, most of them 71-80 years (34.9%, heart failure group, 35.2%, non-heart failure group), with diabetes being the most common comorbidity. (37.4% in both groups). The data were provided by IQVIA’s Disease Analysis Database.

“This is an observational study and the results do not prove that heart failure causes cancer,” said senior authors Mark Rude, PD Dr, MHBA, and Kiel’s Christian Albrecht University in Cardiology. Bremerhaven, Germany said. In the statement.. “But the findings suggest that patients with heart failure may benefit from cancer prophylaxis.”

Recognizing the importance of comorbidity often found in individuals with heart failure, the authors write that cancer has received increasing attention lately, but requires additional data “especially with respect to individual tumor types.” It was.

During a 10-year follow-up period, the authors analyzed heart failure and non-heart failure groups (all). P <.001), respectively:

  • Overall incidence of cancer: 25.7% vs 16.2%
  • Overall incidence of female patients: 28.6% vs. 18.8%
  • Overall incidence of male patients: 23.2% vs. 13.8%

There was also a statistically significant association with cancer incidence (all). P <.001):

  • The overall hazard ratio (HR) was 1.76 (95% CI, 1.71-1.81).
  • Cancer risk increased by 85% in female patients with heart failure (HR, 1.85; 95% CI, 1.77-1.92)
  • Cancer risk in male patients increased by 69% (HR, 1.69; 95% CI, 1.63-1.76)

Nine specific cancer types were also investigated, and the authors saw the following incidence among patients with heart failure:

  • 110% higher risk of cancer of the lips, oral cavity and pharynx (HR, 2.10; 95% CI, 1.66-2.17)
  • 91% higher risk of respiratory cancer (HR, 1.91; 95% CI, 1.74-2.10)
  • The risk of genital cancer in female patients is 86% higher (HR, 1.86; 95% CI, 1.56-2.17).
  • 83% higher risk of skin tumors (HR, 1.83; 95% CI, 1.72-1.94)
  • 77% higher risk of lymphatic and hematopoietic tissue cancer (HR, 1.77; 95% CI, 1.63-1.91)
  • 75% higher risk of gastrointestinal cancer (HR, 1.75; 95% CI, 1.64-1.87)
  • 67% higher risk of breast cancer (HR, 1.67; 95% CI, 1.52-1.84)
  • 64% higher risk of genitourinary cancer (HR, 1.64; 95% CI, 1.48-1.81)
  • 52% higher risk of male genital cancer (HR, 1.52; 95% CI, 1.40-1.66)

“The particularly high incidence of oropharyngeal cancer in patients with heart failure suggests that common extrinsic risk factors such as nicotine can trigger comorbidity,” the authors write. I will.

When speculating on possible reasons for the association between heart failure and cancer incidence, the authors write that the role of increased chronic inflammation or free radical formation, and that heart failure may promote tumor growth through upregulation of certain proteins. Animal studies suggest Serpin A3 and A1 assuming there is. Fibronectin, ceruloplasmin, and paraoxonase 1.

Further research to “clarify this relationship” they saw, with a particular focus on enhanced tumor screening, to better protect patients with heart failure and improve their cancer prognosis. Said it was necessary.


Roderburg C, Loosen SH, Jahn JK, and other heart failure are associated with an increased incidence of cancer diagnosis. ESC Heart Fail. Published online on June 28, 2021. doi: 10.1002 / ehf2.13421


What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

Pictures Credit


to request, modification Contact us at Here or [email protected]