Health
Northwestern uses a drop of blood to develop a coronavirus antibody test
Researchers at Northwestern University Coronavirus antibody Test that they can be completed using only one drop of dry blood from the finger prick they say. A test specially designed to search for SARS-CoV-2 antibodies IgM and IgG says, “How effective policies such as social distance and school and restaurant closures work to prevent viral infections.” The need for clinical practice, according to the team’s lead author, helps to assess what’s happening.
Biological anthropologist Thomas McDade said the test would also help “check the true prevalence and mortality of infections.”
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Researchers have developed a protocol based on two dried blood spots to test the SARS-CoV-2 IgG antibody. The person being tested should be pricked with a finger to improperly take a small blood sample and store it on special filter paper. The same is sent to the lab via a regular mailing service, where researchers use an enzyme-linked immunosorbent assay (ELISA) to detect IgG for the receptor binding domain (RBD) of the spike protein. This is how the virus invades human cells. According to the news release.
“RBD is part of the spike protein and is very“ immunogenic ”. In other words, it elicits a strong response from the immune system that includes the production of RBD-specific antibodies. “McDade says. In a news release. “Thus, we can measure antibodies to RBD as a measure of previous exposure with a high degree of sensitivity and specificity.”
Sampling of dried blood spots has broadened its potential for widespread use because people can conveniently and conveniently sample their blood at home in a cheap and painless way, McDade said.
“By not requiring people to come to the clinic to draw blood, we save clinical resources, keep people safe at home in shelters, and greatly expand the potential reach of antibody testing.” He said in a news release.
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The next step, McDade said, is to test more samples, assess the sensitivity of the test, and develop a web-based platform for deploying antibody tests throughout Chicago.
So far, some studies on antibody testing have produced surprising results, suggesting that the number of individuals infected with COVID-19 is much higher than the number confirmed by the local health department. I am. Some local authorities have cited the need for extensive testing as the region began to carefully resume its economy and local business.
The FDA recently updated its COVID-19 antibody testing policy to crack down on companies offering unapproved “home” testing. As of Monday, the FDA has granted emergency approval for 12 tests, and more than 200 are currently under review.
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“We will continue our work to prevent illicit tests from entering the United States, stay alert to states, hospitals and consumers and make informed purchasing decisions regarding these tests. Is encouraged, “FDA said. “Importantly, those who use antibody tests need to understand their limitations and use the test results as part of the data to inform decision-making. May provide incorrect results. “
The FDA advised that antibody testing should only be used as part of a “well thought out test plan”.
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