Health
Replacement therapy may save the brain from Alzheimer’s disease
Protein replacement therapy may save the brain from Alzheimer’s disease, says researchers at the University of California, who published a new study on Monday.
Neurology professor Alberto Espy is frustrated The FDA recently approved the drug He says it is based on a false theory. He says the problem is not a mass of plaque, but a lack of liquid protein. He says this protein is needed in its original soluble form to keep the brain healthy.
Proteins can also aggregate in amyloid plaques, but Espay says it doesn’t matter.
“No matter how high amyloid is, if you can maintain the level of the soluble fraction of a product that is a normal protein, you can do very well. This is the opposite theory to the general one. “Forever,” says Espay.
UC research conducted in collaboration with Karolinska Institute In Sweden, it is published in the journal EClinical Medicine (published by The Lancet).
Espy says he understands why scientists were confused when conducting autopsy studies. “Of course, we saw this abnormal protein mass, so it was natural and local to think this was a problem.”
Since then, doctors have focused on treatments to remove plaque, including recently approved drug prescriptions.
But Espay says replacement therapy is the right approach, rather than removing plaque. UC and Karolinska are working on one and are testing the findings in animal models.
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