Health
Diverted Drugs Give Hope to Battle of Covid in India
On Wednesday, the country’s apex body for health research, the Indian Council for Medical Research (ICMR), will treat Covid patients with one such drug, lopinavir / ritonavir (HIV / AIDS, for treatment and prevention). Approved fixed-dose combination of drugs used in.
It issued detailed guidelines stating that the drug combination can be used to treat inpatients of moderate severity, such as dyspnea and newly developed organ dysfunction.
But this is not the only drug under consideration. ICMR includes lemdecivir (originally developed for the treatment of Ebola), mycobacterium W (first developed for the treatment of leprosy), disulfiram (a drug for treating alcoholism), resveratrol (clinical stage). Have identified more than a dozen other drugs, including natural compounds of grapes) in Heart and other disorders that can be used to treat Covid-19).
Some of these drugs are in clinical trials in India, sources said.
The ICMR says no effective treatment has been recommended for novels so far Coronavirus, Except for meticulous supportive care.
In the Covid battle, drug diversion is an inexpensive and time-consuming option
The protocol released by ICMR on the use of ropinavir / ritonavir combination therapy is based on an observational study on the clinical benefit of patients with SARS-CoV and MERSCoV and a docking study conducted by the National Institute of Virus Pune. I am.
SARS and MERS are two outbreaks in 2002 and 2012, respectively, also caused by coronaviruses.
Covid-19 Patients receiving anti-HIV drug combinations in hospitals must obtain written consent from the patient. Also, such patients should be enrolled in this protocol on a case-by-case basis.
Hospitals need to carefully monitor patients to produce reliable data on clinical, laboratory, and safety results.
“The results of the first few treatments will help provide guidance on clinical management of future Covid-19 cases,” said ICMR. Board Secretary-General Balram Bhargava was actively involved in the development of treatment protocols using anti-HIV drugs.
Recently, the ICMR has approved the use of the antimalarial drug hydroxychloroquine for the preventive use of health care workers. According to sources, AIIMS Delhi, AIIMS Bhopal, LNJP, Sir Ganga Ram Hospital and others are involved in ICMR to assess the effectiveness of ICMR in preventing infections among healthcare workers.
AIIMS Bhopal Director-General Dr. Thurmansin said it takes time to develop a new drug for Covid-19. “Drug diversion is much easier and is a viable option for finding a cure for Covid-19, so multiple studies have been conducted to identify drug combinations used to treat other coronaviruses. It’s happening all over the world. For example, SARS and MERS will see if Covid-19 can also be treated. ”Dr. Shin also evaluated the use of Mycobacterium W to boost the patient’s immune system. He added that he is conducting clinical trials to see if his / her body can help fight the disease.
Scientists say most diverted drugs have already passed Phase I trials, requiring less investment to prove their efficacy against new diseases or conditions. “Drug diversion strategies reduce development time,” said an article in the Indian Journal of Medical Research.
“Drugs aimed at identifying candidate drug compounds centered on target-based criteria can be distinguished between virus-based and host-based therapies,” the article adds.
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