Health
Scientists Discover New Post-Infection Treatment for Covid-19
Scientists have succeeded in identifying post-infection treatments for SARS-CoV-2, the virus that causes COVID-19, and demonstrating its effectiveness in blocking viral replication in mice.
The study, published in the National Academy of Sciences journal Proceedings, found that animal models infected with SARS-CoV-2 and treated with inhibitors of protease enzymes significantly increased survival and reduced lung viral load. It shows that.
These protease inhibitors are a class of antiviral drugs that prevent viral replication by selectively binding to viral enzymes and blocking the activation of proteins required for the production of infectious viral particles.
“We have developed the protease inhibitor GC376 to treat the deadly coronavirus infection in cats, which is currently in commercial development as a new veterinary drug under investigation,” said Kansas State University, USA. Associate Professor Kim Yoon Jung said.
“After the advent of COVID-19, many research groups reported that the inhibitor was also effective against the coronavirus that causes COVID-19, and many are now pursuing the development of protease inhibitors as a treatment. “I have,” Kim said.
The research team modified GC376 using a tool called deuteration and tested its effectiveness against SARS-CoV-2.
Treatment with deuterated mutants starting 24 hours after infection significantly increased mouse survival compared to untreated mice, the researchers said.
The results suggest that the deuterated mutant has excellent potential as an antiviral agent against SARS-CoV-2, they said.
“Treatment of SARS-CoV-2 infected mice with dehydrogenated GC376 significantly improved survival, viral replication in the lungs, and weight loss, demonstrating the effectiveness of antiviral compounds,” Kansas said. State University professor Chang Kyung-ok said.
“The results suggest that deuterated GC376 has potential for further development, and this deuteration method can be used for other antiviral compounds to produce potent inhibitors. “Chan said.
Virgologists continue to develop improved inhibitors using a variety of methods. The deuterated GC376 is currently being evaluated for further development potential.
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Sources 2/ https://www.indiatoday.in/coronavirus-outbreak/story/scientists-find-new-post-infection-treatment-for-covid-1824049-2021-07-05 The mention sources can contact us to remove/changing this article |
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