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Experts say promising drugs can be found faster than vaccines

 


Lab technicians operate a machine to clean empty vials of the coronavirus disease (COVID-19) drug lemdecibir under investigation at the Gilead Sciences facility in Ravern, California, USA, on March 18, 2020. I will.

Gilead Science Co., Ltd. | Reuters

Scientists argued that diverting existing drugs was a faster way to tackle the coronavirus pandemic than to develop a vaccine.

so Paper published on Thursday In the British Journal of Pharmacology, a team of international experts said there was no “silver bullet” to treat Covid-19, Viral drugs take less time than deploying a vaccine.

According to the paper, biotechnology experts say that it may take more than a year for an effective and scalable vaccine to reach the market, and that developing a safe-to-use vaccination will take between 12 and 18 months. I repeat my earlier claim.

Steve Alexander, associate professor of molecular pharmacology at Nottingham University and one of the authors of the paper, suggested that drugs currently used to treat other diseases could be “diverted.”

“It’s unlikely that you’ll have one magic bullet. You probably need some medicine in the arsenal. Some medicine needs to be used in combination with other medicines,” he said. “The important thing is that these drugs are cheap and easy to manufacture, so you have reliable access to affordable drugs around the world.”

According to the WHO, there are currently at least 108 Covid-19 vaccines in development worldwide.

But “it will be a long time before these vaccines are effective and can be manufactured to the scale needed to impact them,” said Alexander, saying that everything will work. Said that it is not limited. “The more drugs you can test, the more likely you are to get an effective one.”

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Researchers have proposed testing drug therapies that target the portion of human cells to which the Covid-19 virus attaches.

“All the drugs that treat Covid-19 need to focus on three main stages of infection: first the virus prevents it from entering the cell, and if it enters the cell, it stops replicating, It reduces the damage done to the tissue. In this case, the lungs and heart. ” Anthony Davenport said he is a professor of cardiovascular pharmacology at the University of Cambridge and one of the authors of the review.

Researchers say that there are two important proteins on the cell surface that coronavirus binds to, which enable the coronavirus to enter the body and replicate. One of these proteins, known as TMPRSS2, appeared to be common, while the other ACE2s tended to be present at low levels, but were predisposed by gender, age, and smoking history. The rate has increased.

Davenport can accelerate the development of effective treatments for coronaviruses by tracking existing drugs that function by targeting these proteins.

“We can focus on diversions of drugs that are already regulatoryly approved or are in later stages of clinical trials,” he said. “If they can now be shown to be effective at Covid-19, they could be brought into clinical use relatively early.”

The scientist behind the paper said Gilead ScienceLemdecivir, a drug developed to treat Ebola, was a “promising candidate”. Last week Grant emergency permit For use in the United States, it helped reduce recovery time in Covid-19 patients hospitalized after the data showed it.

However, this paper emphasized the importance of acting quickly to identify potential drugs. The researchers speculated that the virus case would likely fall in the summer. That meant fewer people could participate in clinical trials before the second wave of the virus in the fall.

The paper estimates that there are more than 300 clinical trials in the world, but scientists warned that many drugs being studied are unlikely to be effective for widespread use.

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