Moderna’s first seasonal flu vaccine slips into the clinic as pharmaceutical giants flock to mRNA

Now that mRNA technology is backed by the FDA, Moderna has taken the next step. This is a vaccine to improve your annual flu shot. Many major pharmaceutical companies are sucking biotechnology.

Based in Cambridge, Massachusetts, the company has become famous for the success of the COVID-19 vaccine. Administered to the first patient Phase 1/2 clinical trial of new seasonal influenza vaccine.

Moderna is developing mRNA-1010 to protect against common influenza strains recommended by the World Health Organization. The company wants to improve traditional flu shots, which are usually about 40% to 60% effective. Most of these shots were developed using eggs, and Moderna states that it can cause unintended changes in the vaccine virus. The strain used for the vaccine is also determined 6-9 months in advance. In short, much speculation is needed as to which strains predominate during the flu season.

The mRNA-1010 clinical trial will eventually enroll 180 healthy adults to test vaccine safety, patient response, and vaccine efficacy.

Relation: Modana is advancing the outlook for early-stage mRNA to show depth beyond COVID-19 shots

Moderna enters a clinic surrounded by giants on all sides, from Sanofi to Pfizer to GlaxoSmithKline. They believe in the success of the COVID-19 vaccine and believe that mRNA is a new frontier in vaccine development.

Sanofi, in collaboration with Translate Bio, First human experiment One of June’s seasonal mRNA flu vaccine candidates beat Moderna and other rivals to the clinic.

This technique works by teaching the patient’s cells to make proteins that provoke an immune response in the body, stimulate antibody production, and promote protection from viruses. The approval of the COVID-19 vaccine indicates that mRNA was first approved by regulators, but the technology has been studied for decades.

Moderna has previously used the mRNA vaccine in trials with specific influenza strains. In 2019, we removed early data from several Phase 1 tests showing that mRNA vaccines against the H10N8 and H7N9 influenza viruses were “tolerated and elicited a strong immune response.” “”

This latest attempt aims at a wider range using a seasonal approach targeting multiple strains, including influenza A H1N1, H3N2, influenza B Yamagata and Victoria.

Pfizer, which developed the mRNA COVID-19 vaccine that beat Moderna to the US market last year, believes that mRNA will dominate the future of pharmaceutical giants. The company believes that the 95% efficacy seen with the COVID-19 vaccine could lead to a significant improvement in annual influenza vaccination.

Last month, Sanofi announced plans to invest $ 476 million annually in the mRNA Center of Excellence, a dedicated vaccine, to become a leader in the development of mRNA vaccines against a variety of infectious diseases.

Relation: Sanofi invests $ 476 million annually in RNA vaccine centers to extend technology beyond COVID-19

And then there is GSK. Working with CureVac About five clinical stage mRNA-based vaccines through a $ 294 million transaction.

In addition to influenza, Moderna is developing vaccines for HIV, syncytial virus, etc.

Biotechnology is also looking at ways to combine several vaccines into a single shot. Other companies, like Novavax, have beaten them there. Already under test COVID in animals-influenza vaccine.

“Respiratory vaccines are an important pillar of the overall mRNA vaccine strategy,” Moderna CEO Stéphane Bancel said in a statement. “Our vision is to develop an mRNA combination vaccine so that people can get one shot each fall to protect their high efficacy against the most problematic respiratory viruses.”

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