Pangolin may have evolutionary advantages over coronavirus

Similar to smoke detectors sounding alarms, certain genes detect when a virus enters the body and alert intruders, triggering an immune response in most mammals. However, according to a recently published study Immunology frontier, Pangolin — Scale-like anteater-like mammals lack two of these virus-sensing genes. This finding is important because although Pangolins can be carriers of the coronavirus, they appear to be able to tolerate it through other unknown mechanisms. Understanding their evolutionary benefits may point to possible treatment options for coronaviruses in humans.

Researchers focused on pangolins, as exotic animals could infect humans with the virus last year, causing the interspecific jumps necessary for the current COVID-19 pandemic to settle (also bats) Has been identified as a potentially infectious substance). To obtain their results, they analyzed the ginseng genomic sequence and compared it to other mammals, including humans, cats, dogs, and cows.

“Our research shows that Pangolins have survived millions of years of evolution without the type of antiviral protection used in all other mammals,” said the Medical University of Vienna, Austria. The author, Dr. Leopold Eckhart, states: “Further research on pangolin reveals how they can survive Virus infection, And this may help devise new therapeutic strategies for people with viral infections. “

In humans, coronavirus can cause inflammation Immune reaction Called a cytokine storm, it worsens the results. The authors suggest that drug suppression of gene signaling may be one of the treatment options for severe cases of COVID-19. Eckert warns that such remedies could open the door to secondary infections. “The main challenge is to reduce the response to pathogens while maintaining adequate control of the virus,” he says. Overactivation Immune system Eckhart says it can be mitigated “by lowering the intensity or changing the timing of the defense response.”

Research specified Genetic differences The effect of these differences on antiviral responses between pangolins and other mammals has not been investigated. Scientists still do not exactly understand how Pangolins survive the coronavirus. gene It may have something to do with it. Eckert added that another gene, RIG-I, which also functions as a sensor for the virus, can protect against coronaviruses and therefore needs further study. This study provides a starting point for a better understanding of the properties of coronaviruses, the body’s response, and the best options for treatment.

---

Follow the latest news on the outbreak of the Coronavirus (COVID-19)

---

For more information:
Immunology frontier, DOI: 10.3389 / fimmu.2020.00939 , www.frontiersin.org/articles/1…immu.2020.00939 / full

Quote:
Sensoukou may have evolutionary advantages over coronaviruses (May 8, 2020)
Acquired on May 8, 2020
From https://medicalxpress.com/news/2020-05-pangolins-evolutionary-advantage-coronavirus.html

This document is subject to copyright. Apart from personal research and fair trade for research purposes,
Portions may be duplicated without written permission. Content is provided for information purposes only.

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos