In a new study assessing the potential of a single-dose intranasal vaccine, researchers found that the vaccine completely protects mice from lethality. COVID-19 infection. Vaccines also block the transmission of the virus from animal to animal. The findings are published in Science Advances.
This study was conducted by a team from the University of Iowa (UI) and the University of Georgia.
Unlike traditional vaccines that require injections, this vaccine is given via nasal drops. The vaccine is a single dose and can be stored at normal refrigerator temperature for up to 3 months. UI Healthcare said in a press release that the vaccine could be easier to administer, especially for people who are afraid of needles, because it is given intranasally.
The vaccine uses harmless parainfluenza virus 5 (PIV5) to deliver the SARS-CoV-2 peplomer to cells, where it stimulates an immune response. This study showed that the vaccine elicits a localized immune response, including antibodies and cell-mediated immunity, and completely protects mice from lethal doses of SARS-CoV-2. The vaccine also appeared to prevent ferret infection and illness and prevent Covid-19 from being transmitted to uninfected cagemates who were not protected from infected ferrets.
Source: University of Iowa
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