Health
Redundant modular networks support proper brain communication
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Remember your phone number, or the directions you just mentioned. That way, your brain will be actively communicating in many areas. Working memory is thought to depend on the interaction between these regions, but how these brain regions interact and properly represent memory remains a mystery.
At Baylor College of Medicine, Dr. Nuo Lee, an assistant professor of neuroscience and a McNair scholar, and his colleagues Brain region Involved in working memory, we found evidence that modular network tissue is important for sustained neural activity.
How brain regions communicate
Li and his colleagues were able to see that each hemisphere of the brain had a separate expression of memory. However, the hemispheres are sometimes tightly tuned so that you can get very consistent information across the hemispheres in your working memory.
In their study, researchers needed to engage mice in simple behaviors and store specific information. They were trained to delay the instructed action for a few seconds. Time dilation Gave researchers the opportunity to see Brain activity During the memory process.
“We saw many neurons working together to fire from both hemispheres of the cortex at the same time. When activity increased in one region, the other region continued closely. I thought the interaction between the hemispheres was the cause of this memory, “says Li.
Li and his colleagues recorded activity in each hemisphere and showed that each made their own copy of the information during the memory process. So how do the two hemispheres communicate?
Li explained that optogenetics can be used to destroy information in a single hemisphere, in the meantime affecting thousands of neurons. Memory Limits. What they found was unexpected.
“When we are confused hemisphere, Other regions have turned off communications, essentially preventing corruption from spreading and affecting activities in other regions, “Lee said. Not only are they connected to allow the flow of electricity, but they also monitor failures and shut down connections if necessary to prevent failures throughout the power grid. “”
Byungwoo Kang, a student at Stanford University, worked with Dr. Shaul Druckmann and his PhD to develop a theoretical analysis and network simulation of this process. This modular tissue in the brain is important for the robustness of sustained neural activity. I showed that there is. This robustness may be related to the brain’s ability to withstand certain injuries and protect cognitive function from distractions.
“Understanding the redundant modular tissue of the brain brainNatural information processing. ”
Guang Chen et al, Modularity and Robustness of Frontal Cortex Network, cell (2021). DOI: 10.1016 / j.cell.2021.05.026
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Baylor College of Medicine
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