Health
How drug resistance develops in lung cancer
When a doctor administers antibiotics for a bacterial infection to a patient, the entire treatment usually needs to be terminated, even if the symptoms disappear. This is to ensure that the drug kills the remaining bacteria. Raffaella Sordella, a visiting scholar at the Cold Spring Harbor Laboratory (CSHL), investigated similar problems with some lung cancers.
About 15% of non-small cell lung cancers have a mutation in a growth receptor called EGFR that causes tumor cells to grow out of control. Researchers have developed effective drugs that block EGFR and kill cancer cells, but tumors grow later. Sordella wanted to understand the molecular mechanism behind this recurrence and how to prevent it.
Sordella and her team discovered that a small portion of drug-resistant cancer cells were already present before treatment. Instead of relying on EGFR, these cells depend on another gene (AXL) for survival. In addition, they observed that cells could transition between these drug-sensitive and drug-resistant “states.” When the patient finishes EGFR treatment, the remaining cells constantly undergo random changes and both types of cells are restored.
Sordella and her team worked with a Northwell Health clinician and former CSHL professor Gregory Hannon, now at Cancer Research UK Cambridge Institute. Hanon’s research focuses on microRNAs, which are molecules that regulate cells by controlling transcribed (copied) genes. Sordella explains:
“The genome is like a library, so when you have to make a recipe to bake something, go there, copy the recipe, take it out of the library, go to the kitchen. What these microRNAs do Do or they intercept all the recipes you get from the library. Then decide if this is the recipe that the cell needs to care about. Therefore, these are the “gatekeepers” in the cell state. Is called. “
Researchers have discovered that a specific microRNA called miR335 determines the “state” of cancer cells. When a cancer cell loses miR335, a series of events is triggered, allowing the cell to use an alternative AXL pathway. Cells are not killed by drugs that target EGFR. These drug-resistant cells survive and eventually the tumor recovers.
Understanding how resistance develops in lung cancer is the key to understanding how to eliminate the tumor. Sordella hopes that these findings will help develop treatments that will wipe out both AXL-dependent and EGFR-dependent cells from the ground up.
reference: Safaric Tepes P, Pal D, Lindsted T, and other epigenetic switches regulate the ontogeny of AXL-positive / EGFR-TKI-resistant cells by regulating miR-335 expression. eLife.. 2021; 10: e66109. Doi: 10.7554 / eLife.66109
This article was republished from material.. Note: The material may have been edited in length and content. Please contact the citation source for more information.
|
Sources 2/ https://www.technologynetworks.com/cancer-research/news/how-drug-resistance-arises-in-lung-cancer-350827 The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
