Health
MRNA COVID-19 vaccine effective for patients with liver cirrhosis, research results
U.S. veterans who experienced cirrhosis or liver damage and were also given mRNA COVID-19 (New Coronavirus Infection) vaccine One study found a high level of protection against virus-related hospitalizations and deaths.
Findings come as federal health officials said Two groups of concerns related to the potential use of booster shots This includes people over the age of 75, people with weakened immunity, or immunocompromised patients. The authors of the study at hand said, “Patients with cirrhosis have immune dysregulation associated with decreased vaccine response.” An ongoing study by the FDA and CDC Panel is working to determine if, when, and for whom booster shots are needed. But for now, the FDA and CDC have cited highly effective vaccines, saying that “fully vaccinated Americans do not need booster shots at this time.”
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Researchers at Bruce W. Carter VA Medical Center in Miami Published survey results On Tuesday, JAMA Internal Medicine compared a retrospective study of 20,037 US veterans with cirrhosis who had been vaccinated at least once at the Veterans Affairs Department with the corresponding controls of 20,037. Researchers conducted the study using national data from the Veterans’ Liver Disease-Related Outcomes and Costs (VOCAL) Cohort.
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The results suggested that vaccination with Pfizer or Moderna jabs reduced COVID-19 infection in patients by 64.8% and 100% reduction in COVID-19-related hospitalizations or mortality after 28 days. However, patients with further impaired liver function (or decompensated cirrhosis) have 50.3% vs. 66.8 protection against COVID-19 infection, respectively, compared to patients with compensated cirrhosis or asymptomatic stages. The second dose increased, though it was up to 78.6% protection against infection. The authors noted the otherwise “significant knowledge gap” associated with vaccine efficacy in patients with cirrhosis, especially those with decompensated disease.
Notably, vaccinated and unvaccinated patients faced a similar number of infections within 28 days of the first dose, but the benefits of vaccination were 28 days later. It was reported.
Patients under study are on average about 69 years old, with more than 97% of individuals in each study group being male and 60.6% being Caucasian, said to reflect the U.S. veterans population. Included a “significant proportion” of black patients. At 23.2%.
“In this cohort study of U.S. veterans, RNA vaccine administration was associated with a delayed but moderate reduction in COVID-19 infection, but COVID-19-related hospitalization or COVID-19-related hospitalization in patients with cirrhosis. It was found to be associated with a significant reduction in mortality, “the author writes.
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The authors of the study said that patients with cirrhosis elicited a limited response to other vaccines, but mRNA COVID-19 shots resulted in a reduction in coronavirus infection.
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