Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the etiology of COVID-19 (Coronavirus Disease 2019). To date, the COVID-19 pandemic has confirmed more than 190 million SARS-CoV-2 infections and more than 4 million COVID-related deaths.
This pandemic follows the last two global pandemics. Coronavirus, 2002-2003 SARS and 2012 Middle East Respiratory Syndrome (MERS). With a new variant of SARS-CoV-2, the crisis poses an imminent threat despite vaccination programs and ongoing mitigation measures. In addition, personal protection against infection needs to be improved.
SARS-CoV-2 infection is mainly transmitted from aerial virions. The main site of infection in the human body is the nasopharyngeal epithelium, especially the ciliated cells. The lining of the epithelium of the nose is an essential portal for viral infections. It is also an important site for virus replication.
Therefore, the nose is an important target for prevention and treatment.In a recent study posted on bioRxiv* Preprint server, Fabio Fais et al. We have developed a safe and easy-to-use nasal spray AM-301. This is a medical device sold as Bentrio to protect against infection by SARS-CoV-2 and other viruses.
Researchers test safety and Effectiveness of AM-301 countered SARS-CoV-2 and was shown to be safe for the nasal epithelium. The study also significantly reduced virus titers.
The mechanism of action of AM-301 is physical. In other words, the ingredients are non-pharmaceutical because they are neither metabolized nor absorbed. As an additional benefit, researchers noted that sprays could be used against a variety of viruses, allergens, and contaminants in the air.
Researchers have developed a simple and safe intervention to protect and enhance the nasal barrier function against SARS-CoV-2 using natural substances with a wide range of pharmaceutical applications and virus-capturing properties such as clay. did.
Bentonite is a clay mineral composed of a thin sheet of aluminum silicate with a net negative charge. The team has developed a nasal drop containing bentonite (aluminum silicate) in a matrix consisting of monoglyceride, diglyceride, triglyceride, propylene glycol, xanthan gum, mannitol, EDTA disodium, citrate, and water.
Bentonite has long been known to be able to capture viruses, but this study is the first application in the capture of aerial viruses.
The formulation AM-301 is characterized as a white to light beige, odorless, tasteless aqueous gel emulsion with a pH of 6.0. “When we applied it to our own nasal mucosa or palm skin, it had a coherence like a soothing non-irritating lotion,” the paper’s researchers explained. ..
“We have selected only inactive ingredients, such as pharmaceutical additives and generally accepted substances, to minimize potential side effects and promote frequent and compliant use.”
Researchers used MucilAir, an established model of the human primary nasal epithelium, to prevent AM-301 from 1) infecting SARS-CoV-2 and 2) previously established with MucilAir. We have demonstrated that we can reduce the infections that have occurred. processing.
AM-301 in alleviation of SARS-CoV-2 infection. A bar graph containing A, B means and individual data points. The test material was applied 24 hours or 30 hours after the start of the experiment (Protocols 1 and 2 respectively). C linear mixed effect model. The log-linear scatter diagram shows the individual log-transformed data and concave curves of the negative control samples (untreated, saline and matrix treated inserts, dashed curves) and AM-301 treated inserts (continuous curves) (t =). 3.68, p <0.01). This model shows a slowdown in exponential growth, as is usually observed in sigmoid motion.
AM-301 did not adversely affect Mucil Air, except for a slight decrease in ciliary beating frequency, despite repeated application for 4 days. Researchers believe that this may be due to the viscosity of the formulation.
“The positive effect of AM-301 on reducing SARS-CoV-2 infection is supported by observations from a linear mixed-effects model that showed a significant slowdown in viral titer growth in both prophylactic and mitigation assays. Has been done. “
In the early stages of SARS-CoV-2 infection, the nasal passages are known to be infected with high levels of virus. As a result, infected individuals are highly contagious and are at risk of developing lower respiratory tract infections due to aspiration along the nasal-oropharynx-pulmonary axis. “Therefore, the nasal microenvironment plays a major role in SARS-CoV-2 infection and the clinical course,” the researchers observed.
The nasal passages provide two lines of protection: the physical line of protection, the epithelium of the nasal mucosa, and the immune protection provided by immune cells present in the nasopharyngeal lymphoid tissue.
“Together, mucous fimbria clearance and immune response should protect the nasal epithelium from pathogens, but infection can occur in the case of high viral exposure or dysfunction of these mucosal defenses.”
Despite the strong nasal barrier, the virus often succeeds in invading the body. No cure is currently available. AM-301 can be used as a non-pharmacological nasal spray to prevent SARS-CoV-2 infections or to mitigate existing infections.
The promising results of this study require further investigation In vivo In humans, researchers are writing to further evaluate AM-301 as a medical device with a wide range of effects on a range of viruses, allergens, and pollutants.
bioRxiv Publish preliminary scientific reports that should not be considered definitive as they are not peer-reviewed, guide clinical practice / health-related behaviors, and should not be treated as established information.
- Drug-free nasal drops as a barrier against SARS-CoV-2 infection: Safety and efficacy in human nasal respiratory epithelium, Fabio Fais, Reda Juskeviciene, Veronica Francardo, Stéphanie Mateos, Samuel Constant, Massimo Borelli, Ilja P. Hohenfeld, Thomas Meyer, bioRxiv 2021.07.12.452021; Doi: https://doi.org/10.1101/2021.07.12.452021, https://www.biorxiv.org/content/10.1101/2021.07.12.452021v1
The mention sources can contact us to remove/changing this article
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]