A potentially game-changing treatment for people with or at risk of blood clots has been found to be effective by an international team of researchers led by Jeffrey Weitz at McMaster University.
Witz’s team compared averasimab with enoxaparin as a control in 412 patients undergoing knee replacement. The results showed that a single injection of averasimab prevented blood clots for up to 1 month after surgery, reducing the risk by about 80% compared to enoxaparin without increasing the risk of bleeding.
Their findings were published today in the New England Journal of Medicine, consistent with Witz’s presentation at the 2021 International Thrombosis and Hemostasis Society Conference.
Hematologist Weitz is a professor of medicine, biochemistry and biomedicine at McMaster University’s Michael G. DeGlute School of Medicine and Secretary-General of the Institute for Thrombosis and Atherosclerosis.
“Patients undergoing total knee arthroplasty regularly receive anticoagulant treatment with enoxaparin or other anticoagulants that require daily administration,” he said.
“A single injection of averasimab after surgery was found to provide far better protection against blood clots in the veins of the legs compared to one of the current standard treatments, enoxaparin.”
Patients enrolled in the study were closely monitored for symptoms or signs of clotting or bleeding and underwent an X-ray examination of the veins in the operated legs to detect possible thrombosis.
The potential of Avellasimab to treat other cardiovascular diseases has excited Weitz and his fellow scientists.
This success of averasimab in this study provides the basis for its use in the prevention of stroke in patients with atrial fibrillation, in the treatment of deep vein thrombosis and pulmonary embolism, venous thrombosis in the legs and thrombosis in the lungs. cancer. “
Jeffrey Weitz, Hematologist, McMaster University
Avellasimab is an antibody that binds to both the inactive and activated forms of factor XI, one of the coagulation factors, and prevents its activation and activity, thereby stopping clot formation.
This study proved that factor XI was an important driver of clot formation after surgery, and the fact that averasimab was more effective than enoxaparin, which inhibits coagulation factors downstream of factor XI, He added that he emphasized the importance of Factor XI in blood clot formation.
“Patients with congenital factor XI deficiency have a lower risk of blood clots, but spontaneous bleeding is rare, so factor XI is a safer target for new anticoagulants than currently available anticoagulant targets. I’m hoping there is, “he said.
Patients undergoing orthopedic surgery, such as total knee arthroplasty, are at risk of blood clots in the veins of the operated legs, so new anticoagulants may be tested first, according to Weitz. Often. Therefore, different doses of drugs can be evaluated to identify effective and safe drugs compared to standard treatments such as enoxaparin.
These doses can then be carried over to the study of patients with clots or at risk of clots such as cancer-related clots or stroke prevention in patients with atrial fibrillation.
The study was funded by Anthos Therapeutics, a Cambridge-based, Massachusetts-based developer of Avellasimab.
Verhamme, P. , et al. (2021) Avellasimab for the prevention of venous thromboembolism. New England Journal of Medicine. doi.org/10.1056/NEJMoa2105872..
The mention sources can contact us to remove/changing this article
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]