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Research shows men have high levels of enzymes that are key to COVID-19 infection




LONDON (Reuters) -Men’s blood levels of the major enzyme used by the new coronavirus to infect cells are higher than those in women, shown on Monday as the result of a large European study -Discovery that may help explain why men are more susceptible to infections COVID-19 (New Coronavirus Infection) (# If there is no character limit, add parentheses when first appearing.

Angiotensin converting enzyme 2 (ACE2) is found in the heart, kidneys and other organs. COVID-19, a respiratory disease caused by a novel coronavirus, is thought to play a role in how infections progress to the lungs.

This study, published in the European Heart Journal, also shows that widely prescribed drugs called ACE inhibitors or angiotensin receptor blockers (ARBs) do not lead to higher ACE2 concentrations and are therefore taking them. It turns out that it should not increase people’s COVID-19 risk.

ACE inhibitors and ARBs are widely prescribed for patients with congestive heart failure, diabetes and kidney disease. Worldwide prescription drug sales are in the billions of dollars.

“Our findings do not support discontinuation of these drugs in COVID-19 patients.

According to Reuters tally, the COVID-19 pandemic affects more than 4 million people worldwide, killing about 277,000. Death and infection victims indicate that men are more likely to be ill than women and more likely to develop serious or serious complications.

Voors’ team analyzed thousands of men and women to measure ACE2 levels in blood samples from more than 3,500 heart failure patients in 11 European countries.

Researchers said the study started before the coronavirus pandemic, so patients with COVID-19 were not included.

However, when other studies began to point out ACE2 as the key to how the new coronavirus entered cells, Boaz and his team found a significant overlap with their study.

“ When we found that one of the strongest biomarkers, ACE2, was much higher in men than in women, this could explain why men are more likely to die at COVID-19 than women. I’m aware of this, “said Iziah Sama. A UMC Groningen doctor who co-led the research.

ACE2 is a cell surface receptor that binds to new coronaviruses and can enter and infect cells.

Sama and Voors pointed out that ACE2 is found not only in the lungs, but also in the high levels of the tissues that line the heart, kidneys, and blood vessels, especially the testes.

They said their presence in the testes may partially explain the higher ACE2 concentrations in men, and may explain why men are more vulnerable to COVID-19. ..

Report by Kate Kerland. Edited by Catherine Evans


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