Health
Resistance exercise regulates fat cell metabolism at the molecular level, studies find
Findings from new studies at the University of Kentucky School of Medicine and Health Sciences increase evidence that resistance exercise offers unique benefits to fat loss.
Studies from the Department of Physiology and the Center for Muscle Biology FASEB journal We have found that movements such as resistance regulate the metabolism of adipocytes at the molecular level.
Studies in mice and humans show that in response to mechanical loading, muscle cells release particles called extracellular vesicles, instructing adipocytes to enter fat-burning mode.
Extracellular vesicles were initially understood as a way for cells to selectively eliminate proteins, lipids, and RNA. Recently, scientists have discovered that they also play a role in cell-cell communication.
The study adds a new dimension to how skeletal muscle communicates with other tissues by using extracellular vesicles, says John McCarthy, research author and associate professor at the British Department of Physiology. The doctor says.
As far as we know, this is the first demonstration of how weight training initiates metabolic adaptation of adipose tissue and is important for determining systemic metabolic outcomes. The ability of resistance-induced extracellular vesicles to improve fat metabolism has clinical implications. “
Dr. John McCarthy, Research Author
McCarthy’s research team collaborated with the Muscle Biology Center, led by postdoctoral fellow Ivan Vechetti, currently at the University of Nebraska, and supervised by Dr. Charlotte Peterson, a professor donated by Joseph Hamburg.
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Journal reference:
Vechetti Jr, IJ, et al. (2021) Muscle-derived extracellular vesicles induced by mechanical overload promote lipolysis of adipose tissue. FASEB journal. doi.org/10.1096/fj.202100242R..
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