Researchers immunized mice with nanoparticles that mimic SARS-CoV-2 by displaying multiple copies of the receptor-binding domain (RBD) antigen.
The findings of their protein-based vaccines are published in ACS Central Science.
The team created nanoparticles similar in size to SARS-CoV-2 and decorated them with many RBDs. They were injected into mice with separate nanoparticles containing an adjuvant, given twice at 3-week intervals.
For comparison, they immunized another group of mice with RBD-encapsulated polymersomes, along with nanoparticles containing an adjuvant.
Both groups of mice produced high levels of RBD-specific antibodies, but only surface-decorated nanoparticles produced neutralizing antibodies that prevented intracellular SARS-CoV-2 infection.
Source: American Chemical Society
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