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20,000 volunteers exposed to the colon virus in a potential “Human Challenge Trial”
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Over 20,000 people voluntarily New coronavirus In the “human confidentiality test” that has not yet been formulated. Led by a group called 1Day Sooner, It aims to speed up vaccine development, but it has nothing to do with companies currently working on vaccine development.
The group is looking for healthy volunteers between the ages of 20 and 45 with no underlying illness.
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“We recruit as many people as possible to do this and qualify in advance that they are likely to be able to participate in a challenge trial,” said Josh Morrison. 1 day early Co-founder, I told Nature before. “At the same time, I feel that public policy decisions on challenging trials can be more informative if they emphasize the voices of people who are interested in participating in such trials.”
The Human Challenge Trial deliberately exposes volunteers to infections to study diseases, vaccines and treatments. Similar tests are conducted annually with seasonal flu. As an example, Vaccine Development Center at St. Louis University Provided $ 3,500 to volunteers willing to expose themselves to the influenza virus after receiving either the vaccine or placebo.
“It’s unclear how many people around the world are affected by COVID-19 and how fast the impact is felt,” said the 1Day Sooner website. “Potential consequences are formed by interventions such as social distance, capacity of the healthcare system, potential medications and many other factors. Vaccines can be effective after the peak of infection or after Drug treatment can occur after blunting the effects of COVID-19, but it is clear that COVID-19 will continue to change everyday life until an effective vaccine is fully deployed. ”
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As of Thursday, more than 20,000 people from 102 countries are registered as volunteers to apply for hypothesis trials. The trial of human challenge to the coronavirus has been endorsed by 35 members of the House of Commons, who wrote to the Food and Drug Administration and the Department of Health and Human Services, claiming that it should be allowed.
According to the group’s website, this trial, which has no potential start date and may take up to two years to formulate in some estimates, enrolls volunteers likely to have already been exposed to COVID-19. The purpose is to It is isolated in a “highly controlled environment that is constantly monitored.” Participants received vaccine candidates or placebo and were exposed to live coronavirus to allow researchers to determine the efficacy of vaccine candidates.
“If an infection is detected, they will be given excellent treatment,” the group said. “Hopefully, drug treatment will be available by the time the research is done.”
But John Derbin, a vaccine researcher at Johns Hopkins University who was involved in a push that failed a human challenge trial involving the Zika virus, said that one problem with the COVID-19 challenge was the amount of virus exposed to participants. The decision may be to develop a detectable disease.
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“What about the endpoint?” She spoke to Stat News and said.. “You know, do you want to give people pneumonia? I don’t want. You want a somewhat creepy person who knows for sure that you are sick. Whether balance is what it is, or something between a crappy feel and the subsequent onset of pneumonia, I think one of the scariest is not really knowing what it is. “
Morrison Told nature Volunteers are usually “aware of the risks, but believe the benefits of accelerating the vaccine are enormous and valuable.”
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