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COVID-19 results at home with the click of a smartphone




With the resurgence of face-to-face education and the Biden administration’s recently announced vaccine and testing obligations, the rapid and reliable COVID-19 testing continues to be an important factor in controlling the pandemic. Home antigen testing, which gives results within 15 minutes, is now an attractive and convenient option for the general public to quickly find out the status of COVID-19. However, there are significant risks involved. Test results can often be inaccurate.

Microscopic image of microbubbles.

Microbubbles are formed as a reaction to the binding of hydrogen, platinum nanoparticles, and SARS-CoV-2 antigen, and show COVID-19-positive test results. (Image: Pen Medical News)

“When the viral load is low, the antigen test is very insensitive to early infections,” he says. Ping Wang, Professor of Pathology and Laboratory Medicine Perelman School of Medicine.. “You may think it’s safe to go back to work or school after a negative test, but it’s actually infected and infecting others.”

To meet the need for rapid and reliable COVID-19 testing, Wang’s lab Rapid antigen test It can detect small amounts of SARS-CoV-2 with the same sensitivity as the PCR (Polymerase Chain Reaction) test, which is currently regarded as the gold standard in the diagnostic community.

The technology works by using a smartphone camera to capture and measure the size and number of small gas-filled bubbles (called microbubbles) in a chemical reaction using a patient’s nasal swab. increase. Wang and her team validated the test with clinical nasal swabs from 372 patients and found that they could distinguish between 97% of positive swabs and 97% of negative swabs when compared to PCR.The results are published in the journal Clinical chemistry..

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