Health
The Moderna COVID-19 vaccine is effective for 5.3 months after the second vaccination
From July 27 to October 23, 2020, individuals were randomly assigned the first dose and followed up 28 days later.
“Overall, a low incidence of COVID-19 cases was observed in July and August among recently vaccinated participants, but the number we see is the original risk. It’s important to remember that it’s far from returning to, “MD, MD, a physician in the infectious disease department at Brigham and Women’s Hospital in Lindsey Baden, said in a statement.
After the FDA granted Moderna’s Emergency Use Authorization, the COVE trial was modified to monitor individuals who had already been vaccinated and to include two parts that were vaccinated to individuals who were vaccinated with placebo. ..
“The rapid redesign of the COVE trial allows us to successfully retain participants in the trial and test for long-term safety and efficacy,” says Baden. “Using established new research methods, we were able to continue to compare the results of people vaccinated early and late in the study population.”
Fourteen days after the second dose, the researchers found that the vaccine was 93.2% more effective against COVID-19 compared to the placebo group.
Prevention was consistent throughout follow-up and was more than 90% effective more than 4 months after the second dose.
“Overall, our results continue to show that the vaccine is very effective in preventing COVID-19 and is very effective,” says Baden.
“We continue to investigate questions about the duration of immunity after vaccination and the effects of mutants. However, when we look at the potential for weakened immunity, the vaccine is still very defensive. There is evidence that there is, “says Baden.
Safety was also continuously assessed within the group, with adverse events such as fatigue, headache, arthralgia, and myalgia occurring 7 days after vaccination.
Vaccine efficacy was also high in individual subgroups such as age 65 and older, age 75 and older, various ethnic and racial groups, comorbid individuals, and individuals at occupational risk.
“The message here is not that if you are vaccinated early, you are not protected. People who have been vaccinated recently may have experienced slight improvements, but both groups. Benefits from protection compared to unvaccinated people, “Baden said.
The same group of researchers also announced the results MedRxiv We investigated an analysis of individuals vaccinated between July and December 2020 and individuals vaccinated between December 2020 and March 2021.
reference
Results of Phase 3 study: The mRNA-1273 vaccine remained safe and effective for more than 5 months after the second dose. Eurek Alert. news release. September 22, 2021. Accessed on September 23, 2021. https://www.eurekalert.org/news-releases/929287
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