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This groundbreaking coronavirus vaccine has already acted on monkeys – BGR

 


  • The ChAdOx1 nCoV-19 coronavirus vaccine candidate developed by Oxford scientists is already in Phase 1 human trials and may be ready for emergency use in September. According to previous reports..
  • Researchers have published the first study detailing their work on mice and monkeys, and the data suggest that the COVID-19 vaccine can stop the virus from replicating in the body.
  • For more stories, please visit the BGR homepage..

The new coronavirus is here, WHO officials said earlier this week.. Earlier, Dr. Anthony Fauci said that the virus would be unlikely to be eradicated soon or at all. That might sound like bad news, but it’s not. AlreadyAlways viable COVID-19 therapy This will reduce recovery time and prevent complications, which will improve further in the coming months. In addition, more and more companies are developing laboratory-made antibodies that can replicate the success of plasma transfusions from COVID-19 survivors and kill the virus. And the first effective and safe vaccine candidate may be approved for emergencies this fall.

115 teams or more Was working on a vaccine candidate As of mid-April, some of them are in clinical trials. Some of the results have already been incorporated into some of them. Promising oxford drug It may be ready by September. ChadOx1nCoV-19 works in monkeys.

Oxford Scientist Said a few weeks ago “The first millions of vaccines may be available by September,” just as the first phase of human trials has begun.

“Rhesus monkeys are the closest we are to humans,” Dr. Munster said at the time, referring to the six monkeys that were inoculated and exposed to the virus. He said the results of the study that allowed the Oxford team to move into clinical trials will be published soon, and The research is finally over Unreviewed preprinted form.

ChAdOx1 nCoV-19 Made from a virus Called ChAdOx1, this is a weekend version of the common cold virus (adenovirus) that is susceptible to chimpanzees but that also spreads in humans. Researchers added to it specific proteins from the SARS-CoV-2 virus that make the coronavirus spike protein. It is an important component of the virus that allows it to link to the ACE2 receptor on human cells in the nose, lungs, blood vessels and other organs. Researchers use ChAdOx1 nCoV-19 to train the immune system unexposed to SARS-CoV-2 and recognize its spike proteins to stop the virus from attacking the immune response. I would like to develop (antibody).

Image source: Nature A type of technology used to create infectious disease vaccines.

The researchers inoculated 6 monkeys with ChAdOx1 nCoV-19 and observed spike-specific antibodies 14 days after vaccination. They waited another two weeks before administering SARS-CoV-2 to 6 monkeys and a control group. Next, we tested the novel coronavirus in all monkeys and examined both nasal swabs and bronchoalveolar lavage fluid (BAL) from the lungs.

The researchers said the nasal swabs of all animals had the virus, but the BAL test revealed that only two of the inoculated monkeys had the viral genomic RNA in their lungs. Importantly, the virus did not replicate. This is what happens in unvaccinated subjects.

All monkeys were then euthanized and tissue samples taken. The study found that vaccinated monkeys showed no signs of lung pathology consistent with COVID-19. “All lungs were histologically normal and no evidence of viral pneumonia or immune-enhancing inflammatory disease was observed,” the study wrote. In contrast, 2 out of 3 control animals developed some severe viral interstitial pneumonia 7 days after infection.

Studies have shown that even if monkeys have the virus in their nose, the vaccine is effective in preventing viral replication in the lower respiratory tract. “But animals were challenged with high doses of the virus via multiple routes, which is unlikely to reflect realistic human exposure,” he said.

Also important is the fact that the study confirmed that the vaccine candidate did not cause an “immunopotentiating disease in vaccinated animals”.

The data from the study allowed the team to move on to Phase 1 trials. The Phase 1 trial started on April 23 in a cohort of 1,110 patients. This month we will start with a combination of Phase 2 and Phase 3 and can include up to 5,000 people. AstraZeneca Announced partnership with Oxford For global development and distribution of ChAdOx1 nCoV-19.

While these preliminary results are promising, there is no guarantee that they will be successful in human trials or that ChAdOx1 nCoV-19 will be a commercial product in the fight against COVID-19.


A woman in a mask outside is holding a dog. Image Source: Ukrinform / Shutterstock

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Chris Smith started writing about gadgets as a hobby, and before he knew it, he shared his views on technology-related things with readers around the world. He tries desperately when he’s not writing about gadgets, but fails miserably to stay afloat. But that’s not necessarily a bad thing.

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