Connect with us

Health

UM studies reveal why diabetics develop severe COVID-19

Published

on

 


Ann Arbor – A new study from the University of Michigan recently revealed why people with type 2 diabetes are at increased risk of developing severe cases of COVID-19.

Researchers have identified an enzyme called SETDB2, the same enzyme that can make healing of inflammatory wounds in diabetics difficult, likely to be the cause of severe COVID infections.

After witnessing runaway inflammation in COVID patients at the ICU, researcher W. James Melvin decided to see if there was a possible link between the enzyme and the cases they observed.

Working in Catherine Gallagher’s lab at the Department of Microbiology and Immunology, Michigan Medicine, they started with a mouse model of COVID in diabetic-infected mice and observed a decrease in SETDB2 in immune cells affected by the inflammatory response. ..

Immune cells called macrophages responded similarly in diabetic and severely ill COVID patients. In people, researchers observed the same reaction on monocytes-macrophages based on blood samples.

advertisement

“I think there’s a reason these patients have cytokine storms,” ​​Melvin said in a statement.

In both human and mouse models, Gallagher and Melvin said lowering SETDB2 increased inflammation. Their study also revealed a pathway that regulates SETDB2, a macrophage known as JAK1 / STAT3, during active COVID infection.

Their results show potential treatment pathways that may benefit in reversing the patterns that diabetic COVID patients tend to exhibit.

The laboratory previously discovered that interferon, an important cytokine of viral immunity, can increase SETDB2 when it responds to wound healing. As part of a new study, researchers found that sera in ICU patients with diabetes and severe COVID infections were more likely to have lower levels of interferon beta compared to non-diabetic patients. ..

“Interferon is being studied throughout the pandemic as a potential treatment, moving back and forth between attempts to raise and lower interferon levels,” Gallagher said in a statement. “In my sense, its effectiveness as a treatment will be unique to both the patient and the timing.”

advertisement

The researchers were able to reduce inflammatory cytokines and increase SETDB2 in diabetic COVID-infected mice by administering interferon beta.

“We have heard that COVID-19 is increased in IL-1B, TNFalpha, IL-, etc., focusing on those that control SETDB2, one of the many master regulators of these inflammatory cytokines. I’m trying to guess. 6 “Gallerer explained in a statement.

“If you look upstream at what controls SETDB2, interferon is at the top end and JaK1 and STAT3 are in the center. Interferon increases both, which increases SETDB2 in a kind of cascade.”

The importance of identifying a pathway is to present researchers with alternative methods of targeting enzymes, Gallagher said.

“Our study shows that if interferon can target diabetics, especially in the early stages of infection, it can actually make a big difference,” Melvin said in a statement. ..

advertisement

COVID-19 Discussion Forum:

Join the private space and discuss the pandemic. You are invited to share your questions, experiences, insights and opinions.

Join the conversation here.

Copyright 2021 by WDIV ClickOnDetroit-All rights reserved.

..

Sources

1/ https://Google.com/

2/ https://www.clickondetroit.com/all-about-ann-arbor/2021/09/28/u-m-study-reveals-why-diabetics-can-develop-severe-covid-19/

The mention sources can contact us to remove/changing this article

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

ExBUlletin

to request, modification Contact us at Here or [email protected]