Health
Fasting and vitamin C are an effective cancer treatment combination, ending study in mice
There is growing evidence to support the role of fasting in both treatment and prevention of cancer.
Fasting is reduced in some studies to help fight cancer Insulin resistanceAnd the level of inflammation. Also, some researchers are More reactive cancer cells chemical treatmentWhile protecting other cells. Fasting may also boost the immune system and help fight existing cancers.
Now, researchers at the IFC Cancer Institute in USC and Milan say that a combination of a fasting diet and vitamin C supplementation may delay tumor progression in multiple mouse models of colorectal cancer. I found that. They even found that it causes disease regression in some mice.
Valter Longo, lead author of the study and director of the USC Longevity Institute at the Department of Gerontology, USC Leonard Davis, said: “For the first time, we show how a completely non-toxic intervention can effectively treat highly invasive cancers.
“We have taken two widely studied therapies as an intervention to slow aging (a fasting diet and vitamin C) and combined them as a powerful treatment for cancer.”
Report published in journal Nature Communications, The authors note that while fasting remains a challenging option for cancer patients, a safer and feasible option is a low-calorie, plant-based diet that causes cells to respond like the body is fasting. I will.
Results of previous studies on the fight against cancer The potential for vitamin C is mixed.. However, recent studies are beginning to show some benefit, especially in combination with chemotherapy. In this new study, the research team can enhance the behavior of a fasting mimetic diet to fight high-dose vitamin C tumors by creating an environment that is unsustainable for cancer cells but safe for normal cells. I wanted to know if
“Our first in vitro experiment has shown remarkable effects.” Longo said. “Fasting diet or vitamin C alone alone reduced cancer cell proliferation and slightly increased cancer cell death. But when used together, it had a dramatic effect and almost all Cells have been killed. “
Longo and his colleagues detected this powerful effect only in cancer cells with mutations that are considered one of the most challenging targets in cancer research. These mutations in the KRAS gene indicate that the body is resistant to most cancer-fighting treatments and reduce patient survival. KRAS mutations occur in approximately one-quarter of all human cancers and are estimated to occur in up to half of colorectal cancers.
This study also provided clues as to why previous studies of vitamin C as a potential anti-cancer treatment showed limited efficacy.
The authors say that vitamin C treatment alone triggers KRAS mutant cells to protect cancer cells by increasing levels of ferritin, an iron-binding protein. However, lowering ferritin levels can increase the toxicity of vitamin C. In this finding, scientists also found that colorectal cancer patients with high levels of iron-binding proteins are less likely to survive.
“This study observed how a fast-mimicking dietary cycle could enhance the effects of pharmacological doses of vitamin C on KRAS-mutant cancers.” Said Maira Di Tano, co-author of the IFOM at the FIRC Institute of Molecular Oncology in Milan.
“This occurs through the regulation of iron levels and the molecular mechanisms involved in oxidative stress. The results specifically pointed to heme-oxygenase-1, the gene that regulates iron levels.”
Scientists treat cancer in the same way as low-toxic drugs, in the same way that antibiotics are used to treat infections that kill certain bacteria, but only if the first drug is ineffective. I think it can be replaced with other drugs.
To move toward that goal, they say that they first need to test two hypotheses: their nontoxic combination intervention works in mice, and it appears promising in human clinical trials. Let’s The new study demonstrated both, they said.
Source: Natural communication
Longo. V.D. and others
“Synergistic effect of fasting diet and vitamin C on KRAS mutant cancer”
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