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Cleveland Clinic Tests Breast Cancer Vaccine

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October 27, 2021-Researchers at Cleveland Clinic launch a new study to test vaccines aimed at preventing triple-negative breast cancer, The most aggressive and deadly form of illness.

First phase of Clinical trial Determine the strength of vaccination A dose that patients with early-stage triple-negative breast cancer can tolerate. It also examines the body’s immune response to the vaccine.

“We hope that this study will lead to more advanced trials to determine the efficacy of the vaccine against this highly aggressive type of breast cancer,” said Principal Investigator G. Thomas Bad, MD. rice field. In the statement..

Triple negative breast cancer According to the Cleveland Clinic, it usually does not respond to hormone therapy or targeted treatments. It accounts for about 12% to 15% of all breast cancers, but has a high breast cancer-related mortality rate and a high recurrence rate.

Severe breast cancer is twice as likely to occur in black women, the clinic said. About 70% to 80% of women with a mutation in the BRCA1 gene have triple-negative breast cancer.

Researchers have finally found a vaccine developed at Anixa Biosciences Healthy woman This is to prevent the development of triple-negative breast cancer in the first place.

The vaccine targets the breast-specific lactation protein α-lactalbumin. This is usually not seen after breastfeeding, but it is present in most triple-negative breast cancers. Shot activates the immune system against this “retired” protein and provides protection against new tumors by the protein.

This study Immune system Against protein According to the clinic, it was safe and effective in preventing breast tumors in mice. Studies have also found that a single vaccine can prevent the development of breast tumors and stop the growth of existing tumors.Original research Was announced in Nature medicine In 2010, it was funded by charitable donations from more than 20,000 people over the last 12 years.

New research at the Cleveland Clinic is funded by the Department of Defense and is open to non-clinic patients. The first phase of the study will include 18 to 24 patients who have completed treatment for early-stage triple-negative breast cancer in the last three years and who have no tumor but are considered to be at high risk of recurrence.

During the study, participants will be vaccinated three times every two weeks. According to the clinic, they will be vaccinated with different doses and will monitor side effects and immune response.

Researchers estimate that the study will be completed in September 2022. Subsequent clinical trials will test the vaccine in cancer-free women who are at high risk for triple-negative breast cancer. Usually, these women have mutations in the BRCA1 or BRCA2 gene and are at increased family risk for breast cancer.

“This vaccine approach represents a potential new way to control breast cancer,” said Dr. Vincent Tuohy, the lead inventor of the vaccine and immunologist at Cleveland Clinic, in a statement. ..

He said the vaccine could be applied to other types of cancer tumors, but it will probably take decades for these clinical trials to bear fruit.

“Our translational research program focuses on developing vaccines to prevent age-related diseases such as breast, ovarian and endometrial cancers,” he said. “If successful, these vaccines could transform the way we control adult-onset cancers and increase life expectancy.”

Details on eligibility criteria and registration for the study are as follows: Available at ClinicalTrials.gov..

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Sources

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2/ https://www.webmd.com/breast-cancer/news/20211027/cleveland-clinic-breast-cancer-vaccine

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