Health
New research reveals how Alzheimer’s disease progresses in the brain
A new study traced protein tau replication and diffusion for the first time.
Tau aggregates and protein beta-amyloid are involved in the development of Alzheimer’s disease.
The international study, published in Science Advances at the end of last month, was led by scientists at the University of Cambridge.
inside that, The author wrote Combining chemical kinetics with measurements of tau aggregates or “seed” throughout the brain region shows that replication rates in the human brain can be quantified.
After developing a mathematical model to simulate disease progression and using five different tau quantification methods from postmortem seed amplification assay to tau PET (Positron Emission Tomography) scan of the brain Number of Living Individuals – Researchers said similar rates were obtained for several different datasets.
“Our results suggest that local replication is the major process controlling the overall rate of tau accumulation in the neocortical region, rather than spreading between brain regions since Brack Stage III. The number of seeds doubles approximately every 5 years. Therefore, limiting local replication may constitute the most promising strategy for controlling tau accumulation. [Alzheimer’s disease], “They wrote.
Brack Stage III refers to the third of the six stages of the Braak staging method used to classify the degree of Alzheimer’s disease.
Previously, Medical News Today NoteSome people believed that Alzheimer’s disease progressed when tau seeds spread to unaffected areas of the brain.
The publication adds that these findings may prove important in the development of new therapies.
Alzheimer’s disease is the most common type of dementia.
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