Connect with us

Health

Severity of SARS-CoV-2 reinfection compared to primary infection

Published

on

 


To the editor:

In Qatar, there was the first wave of infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) from March to June 2020, after which about 40% of the population was detected for SARS-CoV-2. Had a possible antibody. Then there were two consecutive waves in the country from January to May 2021, triggered by the introduction of the B.1.1.7 (or alpha) and B.1.351 (or beta) variants.1 This created an epidemiological opportunity to assess reinfection.

Use a national federated database that collects all SARS-CoV-2 related data since the outbreak of the pandemic ( Supplementary appendix, NEJM.org, available with the full text of this letter), investigated the risk of severe illness (leading to acute hospitalization), serious illness (leading to hospitalization in the intensive care unit). [ICU]), And a fatal disease caused by reinfection compared to the primary infection in the national cohort of polymerase chain reaction (PCR)-confirmed infection between February 28, 2020 and April 28, 2021. Record of vaccination. The primary infection was defined as the first PCR-positive swab. Reinfection was defined as the first PCR-positive swab obtained at least 90 days after the primary infection. Reinfected individuals were consistent with primary infected individuals in a 1: 5 ratio depending on gender, age group of 5 years, nationality, and calendar week of PCR test date (Figure S1 and Table S1). Supplementary appendix). The severe, serious, and fatal Covid-19 classifications were evaluated by trained healthcare professionals through individual medical record reviews in accordance with World Health Organization guidelines.

Severity of SARS-CoV-2 reinfection compared to primary infection in Qatar’s population.

Of the 1304 reinfections identified, 413 (31.7%) were B.1.351 variants, 57 (4.4%) were B.1.1.7 variants, 213 (16.3%) were “wild-type” viruses, and 621 (47.6). Was the cause. %) The status was unknown (Section S1) Supplementary appendix). For reinfected individuals, the median time from initial infection to reinfection was 277 days (interquartile range, 179-315).The odds of serious illness at the time of reinfection were 0.12 times (95% confidence interval). [CI], 0.03 ~ 0.31) At the time of primary infection (table 1). When the odds ratio was 0.00 (95% CI, 0.00-0.64), there were no cases of serious illness at the time of reinfection and 28 cases at the time of primary infection (Table S3). There were no deaths from Covid-19 during reinfection, 7 deaths during primary infection, and an odds ratio of 0.00 (95% CI, 0.00-2.57). The odds of a combined outcome of serious, serious, or fatal disease at reinfection were 0.10 times (95% CI, 0.03 to 0.25) at primary infection. Sensitivity analysis was consistent with these results (Table S2).

Reinfection was 90% less likely to lead to hospitalization or death than primary infection. The four reinfections were severe enough to lead to acute hospitalization. None of them led to hospitalization in the ICU and none died. Reinfection was rare and was generally mild, probably due to the primed immune system after the primary infection.

Previous studies evaluated the effectiveness of previous natural infections as a defense against reinfection with SARS-CoV-2.2,3 Assuming that it is 85% or more. Therefore, for those who are already primary infected, the risk of severe reinfection is only about 1% of the risk of severe primary infection for those who have not been previously infected. As with the immunity that occurs against other seasonal “cold” coronaviruses, it is necessary to determine whether such protection against serious illness during reinfection lasts longer.Four It induces short-term immunity to mild reinfection, but it induces long-term immunity to more serious illnesses with reinfection. If this is the case for SARS-CoV-2, the virus (or at least the variants studied so far) may adopt a better infection pattern when it becomes endemic.Four

Dr. Rice J. Abu Raddad
Hiam Chemitery, Master
Weill Cornell Medicine – Qatar, Doha, Qatar

Roberto Bertorini, MD, MPH
Ministry of Public Health, Doha, Qatar

COVID-19 For the National Study Group for Epidemiology

Supported by the Biomedical Research Program and the Core of Biostatistics, Epidemiology, and Biological Mathematics Research. Weill Cornell Medicine – QatarNS Ministry of Public HealthHamad Medical Corporation; and Sidra Medicine. The Qatar Genome Program supported viral genome sequencing.

Disclosure form The one provided by the author is available on NEJM.org with the full text of this letter.

This letter was published on NEJM.org on November 24, 2021.

Members of the National Research Group for COVID-19 Epidemiology are listed in Supplementary appendixAvailable at NEJM.org with the full text of this letter.

  1. 1.1. Abu Raddad LJ, Chemaitelly H, Bat AA.. Efficacy of BNT162b2Covid-19 vaccine against B.1.1.7 and B.1.351 mutants. N Engl J Med 2021385:187――――189..

  2. 2.2. Abu Raddad LJ, Chemaitelly H, Coil P,other. SARS-CoV-2 antibody positivity is 95% effective and prevents reinfection for at least 7 months. EClinicalMedicine 202135:100861――――100861..

  3. 3.3. Abu Raddad LJ, Chemaitelly H, Marek JA,other. Assessment of the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection in a severe re-exposure environment.Clinical infections 202173 (7):e1830――――And 1840..

  4. 4.4. Ravine JS, Bjorn stud ON, Antia R.. Immunological characteristics govern the transition of COVID-19 to the epidemic.Chemistry 2021371:741――――745..

Severity of SARS-CoV-2 reinfection compared to primary infection in Qatar’s population.

The result of the illness*ReinfectionPrimary infectionOdds ratio (95% CI)
number. / No for those with results.Of people with severe, serious, or non-fatal infections
Severe illness4/1300158/60950.12 (0.03–0.31)
Serious illness0/130028/60950.00 (0.00–0.64)
Incurable disease0/13007/60950.00 (0.00–2.57)
Severe, severe, or fatal illness4/1300193/60950.10 (0.03–0.25)

Sources

1/ https://Google.com/

2/ https://www.nejm.org/doi/full/10.1056/NEJMc2108120

The mention sources can contact us to remove/changing this article

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

ExBUlletin

to request, modification Contact us at Here or [email protected]