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CWRU scientists collaborate with Duke and Rutgers has an antiviral purpose in COVID

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Cleveland (WJW) — Scientist Case Western Reserve, Duke University and Rutgers University are working together to understand how the entangled RNA of the new coronavirus can help treat infected individuals.

According to a CWRU news release, a group of scientists have identified compounds that may block the ability to replicate within the coronavirus genome.

In this release, in order for a coronavirus to infect a cell, it invades, sends a genetic command in the form of RNA, hijacks the molecular mechanism of the cell to make a new copy of itself, and makes the infected cell a virus factory. Explains that it needs to be. .. It begins to stir the proteins needed for the virus to replicate and spread.

Read the full research article here:

According to CWRU, remdesivir and molnupiravir, the only antiviral drugs approved or under consideration for protection from COVID-19 by the U.S. Food and Drug Administration, work by binding to these proteins. ..

However, this team is taking a different approach. They say they have identified the first molecule that can target RNA strand folding found in the complex 3D structures of the viral genome itself.

“We believed that the unique shape of the virus’s RNA genome provided an opportunity to target it with small molecules that could slow the spread of the virus,” said Rudolf and Susan Lense, a professor of chemistry in Case. One Brunton S. Tourbat says. Western Reserve, one of the researchers leading the project. “And the initial results are encouraging.”

In a news release, Amanda Hargrove, a professor of chemistry at Duke University, said the study offered the potential for undeveloped treatments to combat COVID-19. “Mechanism in that sense,” she said.

A group of scientists have stated that this finding could lead to the treatment of other future viruses to fight another RNA virus, enterovirus 71, a common cause of hand-foot-and-mouth disease in children. We are already investigating potential drug candidates.

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