Eight years ago, a team of researchers launched a project that carefully repeated early but influential laboratory experiments in cancer research.
They reproduced 50 experiments. This is a type of preliminary study using mice and test tubes to set the stage for new anticancer drugs. Disappointing results were reported on Tuesday: about half of the scientific claims did not hold up.
“The truth is that we fool ourselves. Most of what we claim is novel and unimportant,” he said. Dr. Vinay Prasad, A cancer doctor and researcher at the University of California, San Francisco, who was not involved in the project.
It is a pillar of science that the most powerful discoveries come from experiments that can be repeated with similar results.
Get the free Coronavirus Today newsletter
Sign up for the latest news, the best stories, what they mean to you, and the answers to your questions.
You may receive promotional content from the Los Angeles Times.
In reality, there is little incentive for researchers to share methods and data so that others can verify their work. Marcia McNut, President of the National Academy of Sciences. If the results cannot withstand scrutiny, the researchers will lose fame, she said.
And there are built-in rewards for publishing your findings.
But for cancer patients, reading the headlines of mouse studies that appear to promise treatment “around the corner” can lead to false hopes, Prasad said. “Cancer progress is always slower than we want.”
New studies reflect the early shortcomings of scientific processes, not established treatments. By the time anticancer drugs hit the market, they have been rigorously tested by many to ensure they are safe and effective.
In this project, researchers attempted to repeat the experiment from cancer biology papers published between 2010 and 2012 in major journals such as Cell, Science, and Nature.
Some of the studies that did not hold up found that certain gut bacteria were associated with human colon cancer. The other was a type of drug that shrinks breast tumors in mice. The third was a mouse study of a potential prostate cancer drug.
The co-author of the Prostate Cancer Study said the study conducted at the Sanford Burnham Prebeads Institute has withstood other scrutiny.
“There are many duplicates [scientific] Our resulting literature ” Erkki Ruoslati, Started a company currently conducting human trials with the same compound for metastatic pancreatic cancer.
This is the second major analysis by the reproducibility project. In 2015, we had a similar problem. I repeated the psychology experiment..
Co-author of the study Brian Nosek Members of the Center for Open Science said it could be wasteful to move forward without first repeating the findings.
“We blow the trumpet to the world, saying,’I have a solution,’ before we start clinical trials, start up a startup, or do any further work to validate it,” Nosek said. Mr. says.
Researchers have sought to minimize differences in how cancer experiments are conducted. Often, I couldn’t get help from the scientist who did the original work when I was asked about the strain of the mouse to use and where to find the specially designed tumor cells.
“I wasn’t surprised, but I’m concerned that about one-third of the scientists didn’t help, and in some cases they didn’t.” Michael Lauer, Deputy Director of Out-of-Wall Research at the National Institutes of Health.
NIH seeks to improve data sharing among scientists by requesting data from granted institutions in 2023, Lauer said.
“Science can produce amazing things when it’s done right,” Lauer said.
For now, I said skepticism is the right approach Dr. Glen Begley, A biotechnology consultant and former head of cancer research at the pharmaceutical company Amgen. Ten years ago, he and other Amgen in-house scientists reported even lower confirmation rates when trying to repeat published cancer experiments.
Researching cancer is difficult, “it’s very easy for researchers to be attracted to exciting and provocative results. The results further support their favorite idea of how cancer works. It looks like it does, but it’s wrong. “
The mention sources can contact us to remove/changing this article
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
- Hospitals in Half of US States Near Capacity as Omicron Continues to Scale | American News January 15, 2022
- Krafton sues Google, YouTube and Apple for alleged PUBG clones January 15, 2022
- Garbage and recyclables are piling up as omicron takes its toll on sanitation workers : Coronavirus updates : NPR January 15, 2022
- Netflix gives green light to ‘Drive to Survive’ team tennis documentary January 15, 2022
- Target fashion finds that appear to be from Zara January 15, 2022