Health
Two common drugs found to be effective against COVID-19 in early tests
Researchers at the University of Florida in the United States say the combination contains diphenhydramine, an antihistamine used for allergic symptoms.
Two over-the-counter drugs have been shown to inhibit replication SARS-CoV-2, The virus that causes COVID-19 (new coronavirus infection), In preliminary tests, according to research.
Researchers at the University of Florida in the United States say the combination contains diphenhydramine, an antihistamine used for allergic symptoms.
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When combined with lactoferrin, a protein found in bovine and breast milk, these compounds were found to interfere with SARS-CoV-2 during tests on monkey and human lung cells.
According to researchers, lactoferrin is commonly used as a supplement to treat gastric and intestinal ulcers, among other uses.
“We have found out why certain drugs are effective against viruses that cause them. COVID-19 (new coronavirus infection).. Since then, we have discovered a combination of antiviral agents that is effective, economical, and has a long history of safety, “said David AOstrov, an associate professor at the University of Florida.
In laboratory tests of human and monkey cells, the drug combination was particularly strong, the researchers said.
Individually, they said that each of the two compounds suppressed SARS-CoV-2 virus replication by about 30%, and together they reduced viral replication by 99%.
The findings, published in the journal Pathogens, are the first step in developing a formulation that can be used to accelerate the recovery of COVID-19.
Additional studies on the efficacy of the compound for COVID-19 prophylaxis are already underway in the mouse model, the researchers said.
To establish their findings, they focused on proteins expressed in human cells known as sigma receptors.
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According to researchers, in the case of COVID-19, the virus “takes over” stress response mechanisms, including sigma receptors, and replicates in the body.
Interfering with its signaling seems to be the key to blocking the efficacy of the virus, they said.
“We now know the detailed mechanism of how a particular drug inhibits SARS-CoV-2 infection,” Ostrov said.
Experimental data show that highly specific sigma receptor binding drug candidates and prescription combinations of commercial products may suppress viral infections and reduce recovery time from COVID-19. I am.
Although the findings are promising, Ostrov warns against self-treatment of either diphenhydramine or lactoferrin as a prophylaxis or treatment for COVID-19.
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He added that the types of lactoferrin used in the study are slightly different from the types commonly available to consumers.
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