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Low staff vaccination associated with death from COVID in nursing homes.Experimental vaccines target multiple coronaviruses

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When South Korea launches a vaccination campaign against coronavirus disease (COVID-19) in Seoul, South Korea on February 26, 2021, care facility workers will receive the AstraZeneca COVID-19 vaccine at the Healthcare Center. REUTERS / Heo Ran

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December 10 (Reuters)-The following is a summary of some recent studies on COVID-19. They require further research to support the findings and include studies that have not yet been certified by peer review.

Vaccination rates for staff related to COVID-19 deaths in nursing homes

A U.S. study found that low COVID-19 vaccination rates for nursing home staff were associated with high coronavirus illness and high mortality rates for residents, even if they were vaccinated. increase.

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Using national data from early June to late August 2021, researchers compared nursing homes with the highest and lowest percentage of vaccinated staff. In areas with high COVID-19 incidence, homes with the lowest staff vaccination rates more than double the number of people who develop COVID-19 and nearly triple the number of people who die.This was true regardless of vaccination rates among residents and other differences between institutions, the researchers reported. Wednesday of the New England Journal of Medicine..

Researchers found that if all nursing homes achieved staff vaccination rates (on average about 80%) at the most vaccinated facilities by mid-June, staff COVID-19 cases would decrease by 7,501 over the next 10 weeks. , Estimated to decrease by 4,775. Cases occurred among residents, and the number of resident deaths due to the virus decreased by 703. Brian McGarry, a research leader at the University of Rochester in New York, strongly suggests that “highly vaccinated staff are important” to protect care facility residents from COVID-19. I’m doing it. “

New types of vaccines target multiple coronaviruses

Researchers hope that the new type of vaccine being developed by the U.S. Army will protect against other respiratory viruses as well as the viruses and variants that cause the current COVID-19 pandemic. ..

Their “Spike Ferritin Nanoparticles” (SpFN) vaccine employs the popular protein ferritin in the form of a “platform” in the shape of a soccer ball. The platform has 24 “faces” on which replicas of the peplomer protein used by some viruses, including coronavirus, to invade cells are mounted. Providing spike replicas via a vaccine teaches the immune system to recognize and attack them in case of infection. The results of completing the first trial of the vaccine in humans are being analyzed.

In laboratory experiments, the researchers said vaccine-induced antibodies protected mice from lethal doses of the virus that caused COVID-19 and the virus that caused the 2003 SARS outbreak. Tuesday’s Cell Reports.. Gordon Joyce, Research Leader at the Walterlead Army Institute in Silver Spring, Maryland, said: He said the vaccine remains stable over a wide range of temperatures and will be particularly useful in areas without special storage equipment.

Cold antibodies can interfere with protection against SARS-CoV-2

Antibodies to the cold virus, collectively known as hCoV, may interfere with the body’s response to SARS-CoV-2, according to new data. Previous studies disagreed on whether previously obtained hCoV antibodies prevent SARS-CoV-2 infection.

Maureen McGargill of St. Jude Children’s Research Hospital in Memphis said: Comparing blood samples before and after people infected with the virus responsible for COVID-19, her team found that SARS-CoV-2 infection increased hCoV antibody levels. This indicates that the virus appears to resemble immunity. system. However, a comparison of 121 people infected with SARS-CoV-2 with 1,081 people not infected showed that high baseline levels of hCoV antibody could not protect SARS-CoV-2.Instead, they reported Cell Host Microorganisms MondayHigher baseline levels of hCoV antibody were associated with higher levels of SARS-CoV-2 antibody, which is a sign of more severe COVID-19.

Researchers found that mice whose immune system was prepared to produce antibodies that attack the cold virus appeared to be less capable of producing antibodies that neutralize SARS-CoV-2. The findings suggest that hCoV antibodies impair the antibody response to SARS-CoV-2. This is probably due to an antibody boost that cross-reacts with SARS-CoV-2 but does not neutralize it, McGargill said.

Click Reuters graphics About the vaccine under development.

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Report by Nancy Rapid; Edited by Bill Berkrot

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