Initial study of COVID-19 patients with diabetes shows that 10% die within 7 days of hospitalization

The first study of COVID-19, which specifically analyzes the effects of disease in inpatients with diabetes, found that 1 in 10 patients died within 7 days of admission and 1 in 5 were intubated. At this point, the person is on artificial respiration. The research is published in Diabetes (European Diabetes Research Journal [EASD]), Professor Bertrand Cariou and Professor Samy Hadjadj, Diabetes Specialist in Chest l’institut du thorax, Nantes University Hospital, INSERM, CNRS, Nantes University in France, and colleagues.

This study shows that two-thirds (65%) of hospitalized diabetic COVID-19 patients are male and the average age of all patients is 70 years. Poor glycemic control did not seem to affect patient outcomes, but due to the presence of diabetic complications and increasing age, death, And BMI are associated with both an increased risk of requiring mechanical ventilation and an increased risk of death.

The CORONADO study analyzed 1,317 patients admitted to 53 French hospitals (public and private) between 10 and 31 March 2020. In the rest cases. In 3% of cases, diabetes was actually diagnosed during hospitalization for COVID-19.

Microvascular complications (eyes, kidneys, nerves) were found in 47% of study subjects, while macrovascular complications (heart, brain, leg arteries) were found in 41% of patients analyzed .. By 7 days, 1 in 5 (20.3%) had been intubated, placed in an intensive care unit ventilator, and 1 in 10 (10.3%) died in all patients in this study. An additional 18% were discharged home at this time.

The presence of microvascular or macrovascular complications more than doubled the risk of death on day 7, respectively. Older age also significantly increases the risk of death, and the group of 75-year-old patients is 14 times more likely to die than younger age patients. Also died three times more. The presence of dyspnea obstructive sleep apnea almost tripled the risk of death on day 7, as did the presence of dyspnea (shortness of breath).

The study also confirmed that insulin, and indeed all therapies for altering blood glucose, are not risk factors for the severe form of COVID-19 and should be continued in diabetics. Encouragingly, there were no deaths in patients under the age of 65 with type 1 diabetes, but only 39 patients with type 1 diabetes in this study, to establish the effect of COVID-19 in this particular population. Other work is in progress. .

Increased BMI increased the risk of reaching the primary overall outcome of the trial (intubation / ventilation or death on day 7). Women were 25% less likely to reach the overall primary endpoint than men (results of borderline statistical significance). However, looking at death alone, men were not statistically more likely to die on day 7 than women.

The author says: ” Risk factor The severe form of COVID-19 is General population: Age and BMI. “

They said, “Elderly people treated for long-term diabetes mellitus and / or obstructive sleep apnea with advanced diabetic complications are at particular risk of premature mortality and are under specific control to avoid new coronavirus infections. BMI also appears as an independent prognosis Factors of COVID-19 severity in a population suffering from diabetes that requires hospitalization. The link between obesity and COVID-19 is Further research is needed. “

The authors will elaborate on the outcomes of approximately 3000 diabetic patients hospitalized at COVID-19, examine their condition 28 days after admission, and present further summer studies. In the next study, we will further compare the presence or absence of COVID-19 outcomes. Diabetes.

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