Health
The likely order of Covid symptoms depends on the coronavirus variant: study
According to one study, the sequence of symptoms most likely to be experienced by patients with Covid-19 varies by variant of the SARS-CoV-2 virus.
Researchers at the University of Southern California in the United States wanted to know if the order of symptoms in Covid-19 was different for patients in geographically different regions, or if they had different patient characteristics.
Identifying the order of onset of infections may help distinguish symptomatic infections early in the population, thereby allowing non-pharmaceutical interventions and reducing the spread of the disease, they said. Stated.
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Published in the journal PLOS Computational Biology, this study used a modeling approach to predict the order of symptoms in a series of 373,883 cases in the United States from January to May 2020.
The most probable sequence of symptoms is the first outbreak in China, where fever is most often preceded by cough, and if nausea or vomiting was the third common symptom, and then to the United States. It was different from the spread.
In the United States, cough was most likely the first sign and diarrhea was the more common third sign.
By analyzing additional data from Brazil, Hong Kong, and Japan, the team found that the different order of symptoms was associated with SARS-CoV-2 variants rather than geographic regions, weather, or patient characteristics. Shown.
The presence of the D614G mutant in areas predominant in the United States in early 2020 was associated with the likelihood that cough was the first Covid-19 symptom experienced by patients.
As Japan moved from the original Wuhan reference strain to the D614G mutant, the order of symptoms also changed, the researchers said.
The authors of the study hypothesize that increased infection with D614G may be associated with the order of symptoms.
“These findings are that mutations in viral diseases can change the order of symptoms, and infected people are more likely to cough in public before the fever goes away, so the D614G variant It shows that it is more likely to be transmitted, “they added.
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