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Prostate cancer drugs may “change game”

 


Friday, May 29, 2020 (Health Day News) -For Seniors Prostate cancer, New hormone therapy drugs work better than standard injections and have a much lower risk heart attack Or stroke, Found a clinical trial.

A drug called lulugorix has not yet been approved by the US Food and Drug Administration. But if it becomes a green light, it will be a “breakthrough change,” said Neil Shore, a senior researcher at the trial.

Hormone therapy has long been the standard treatment for advanced prostate cancer, including when it has spread beyond prostate cancer and has recurred after surgery or radiation.

The goal is to suppress androgen hormones, including testosterone. This is because they promote the growth of prostate tumors.

Today, this is usually done with injectables called LHRH agonists. The problem is that the drug first causes a spike in testosterone before it dramatically reduces hormone levels. The surge can exacerbate cancer-related symptoms such as bone pain and urine problems.

“It’s like racing and telling people to walk back 10 steps first and then start,” said Shore, director of medicine at the Center for Urology Research, Carolina, in Myrtle Beach, South Carolina.

In contrast, lulugorix-taken as a daily tablet-quickly reduces testosterone levels, the study found.

More importantly, there is a low risk of a cardiovascular “event”, defined as a heart attack, stroke, or death from any cause.

Over the course of 48 weeks, the risk was 54% lower among men receiving lurugolix compared to a standard LHRH agonist called luprolix.

“It’s very important,” said Dr. William Cans, chief medical and scientific director of the American Cancer Society.

“This drug checks almost every box,” said Cancer, who was not involved in the study.

He also said more research is needed on the long-term performance of pharmaceuticals. However, if approved, it would be more likely to be favored than LHRH agonists, Cance said.

The survey results are New England Medical Journal (NEJM), And on Friday at the virtual meeting of the American Society of Clinical Oncology.

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