Health
How the COVID virus bypasses the immune defense
Tuesday, December 28, 2021 (HealthDay News) – SARS-CoV-2 avoids humans Immune system Having made scientists mysterious for nearly two years, they have now discovered important clues.
The virus that causes COVID-19 is a stealth movement that hides from the immune system and allows it to spread from cell to cell. New research reveals.
“This is basically a form of underground infection,” said Champagne, research author at the Research Center. Retrovirus A study at Ohio State University in Columbus.
He added that this cell-to-cell infection was not sensitive to antibodies from previous COVID infections or vaccinations.
New study compares SARS-CoV-2 with previous one coronavirus (SARS-CoV) Caused SARS in 2003 Outbreak, And how it sheds light Virus spreads And resist people Immunity..
Also, the first outbreak led to a much higher mortality rate, lasting only eight months, while the current pandemic lasts for two years, often asymptomatic and endless. It also helps to explain.
Cell culture experiments have shown that SARS-CoV-2 limits the release of particles that can be inactivated by human antibodies. Like a stealth warrior, it remains pushed into the cell wall and spreads from one cell to another.
“SARS-CoV-2 can spread efficiently from cell to cell because there is essentially no blocker from host immunity,” Liu explained.
The familiar peplomer on the surface of the virus allows cell-to-cell diffusion. Neutralizing antibodies are less effective against the virus when it spreads through the cells.
Comparing the two viruses, studies have shown that the 2003 virus is more efficient in cell-free infections. This is when free-floating virus particles infect target cells by binding to receptors on their surface. The virus remained vulnerable to antibodies produced by previous infections and vaccines.
However, intercellular infection of the COVID-19 virus makes neutralization by antibodies difficult.
In this study, researchers used a non-infectious pseudovirus and had both types of coronavirus peplomers on the surface.
“Because the only difference between these pseudoviruses was the peplomer, which is necessary and sufficient for intercellular infections of both SARS-CoV-2 and SARS-CoV,” Liu, who is also the director of the virus and emerging pathogens. Says. OSU Infectious Diseases Research Institute program.
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Sources 2/ https://www.webmd.com/lung/news/20211228/how-the-covid-virus-sneaks-past-immune-defenses The mention sources can contact us to remove/changing this article |
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