Continuous doses of hydroxychloroquine and PPE can reduce health care worker COVID-19 risk, according to an ICMR study

Recent research with the World Health Organization (WHO) Lancet Maybe questioned the preventive effects of hydroxychloroquine (HCQ) in reducing COVID-19 risk, but the Indian Medical Research Council (ICMR) says antimalarial drugs minimize the likelihood of contracting health care workers. It continues to argue that it may have limited new coronavirus-especially when used in combination with personal protective equipment (PPE).

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ICMR study recommends maintenance dose

This conclusion is based on the ICMR case-control study and the results are Indian Medical Research Journal (IJMR). This study investigated participants randomly selected from a country-level COVID-19 test data portal managed by the ICMR. Some were COVID-19 positive and others were part of the control group. Participants were given a questionnaire to understand the procedures they carried out and their use of PPE and consumption of HCQ.

On the other hand, studies show that health care workers who perform endotracheal intubation are at a much higher risk of being infected with SARS-CoV-2, and simply taking HCQ did not reduce this risk. On the other hand, the study found that “4 or more maintenance doses of HCQ were associated with a significant reduction in the probability of infection.”

Thus, this study could highlight the fact that there is a dose-response relationship (response is dose-dependent) between the frequency of taking HCQ and the reduction in the number of infections among health care workers. In addition, the findings of this study also showed that “PPE use was independently associated with a reduced probability of being infected with SARS-CoV-2.”

Essentials for healthcare professionals from this study

Well, perhaps your main point in the future is that continued consumption of 4 or more doses of HCQ along with proper use of PPE can also reduce the risk of COVID-19 infection in the general population. However, this is not recommended by ICMR. The results of this study are expected to help protect health care workers at the “front of COVID-19”.

This study clearly shows that HCQ consumption by health care workers must be initiated prior to the onset of infection, and its recommendations are in line with the national task force’s recommended continuous dose. According to the Ministry of Health and Family Welfare (MoHFW), this dose is “400 mg twice daily on day 1 and then 400 mg weekly for the next 7 weeks” for health care workers. The report suggests that if this dose and the use of PPE are adhered to, a reduced risk of COVID-19 infection can be observed from around week 4.

As such, the WHO plans to determine whether the HCQ trial will be discontinued for the next 24 hours, but the ICMR study suggests that continued use of this antimalarial drug is still recommended for frontline healthcare workers. Suggests that

For more information, see the following article. Is hydroxychloroquine really effective against COVID-19?..

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Update: June 2, 2020 13:37:29 IST

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