Health
Why Antibodies Are Ineffective Against Omicron
Studies have shown that a large number of mutations are present, and that the spike protein exceeds 30 to ineffective antibodies against the Omicron variant of Covid-19.
An unprecedented number of mutations, especially in the peplomer (S) protein of the Omicron variant, are associated with its high infectivity and infectivity, according to a peer-reviewed and published study in the Journal of Autoimmunity.
These mutations also make it possible to evade existing antibodies by both infection and vaccination in the human body, explaining the reinfection and increased number of breakthrough cases. Jerusalem Post report.
Read again: Three doses of mRNA Covid vaccine highly effective against Omicron and Delta: Study
Researchers at the University of Missouri have set out to collect data on mutations found in the S protein of the Omicron variant.
The team used the complete sequence of Omicron variants to identify a total of 46 signature mutations within the variant, 23 of which were completely unique and not identified in previous variants of the virus. Two of the mutations were first recorded in the Delta or DeltaPlus variants.
Of the 46 mutations found, 30 were identified with the S protein and the rest were located elsewhere in the viral cells, the report said.
In addition, the team will use existing S-protein structures to theoretically prevent the antibody from binding to the virus, and whether the Omicron mutation will affect the Covid-19 S protein as well and invalidate the antibody. I evaluated it.
Read again: Omicron in India’s community-infecting stage, predominant in multiple metropolitan areas: INSACOG
The team found that certain mutations cause interference on the surface of the virus, preventing the antibody from binding to the virus, and other mutations completely lose the interaction between the antibody and the virus, thereby causing the antibody to be highly mutated. I found it to be invalid for my body. According to the report.
This suggests that existing immunization (whether due to vaccination or previous infection) can no longer provide optimal protection against Omicron variants and can bypass antibodies and enter the immune system. The researchers said.
“The purpose of the antibody is to recognize the virus and stop binding to prevent infection,” said Kamrendra Singh, a professor of veterinary medicine at Varsity.
“But many of the mutations in the Omicron variant have been found to be where the antibody should bind, so how the virus continues to evolve in ways that may avoid or avoid existing antibodies. It continues to infect so many people, “he added.
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