Connect with us


Do Estrogens Affect Alcohol Use Disorders?





Image: Amy Lassek, an associate professor of psychiatry, anatomy, and cell biology, led the study to specifically examine estrogen receptors in the brain and determine which estrogen-mediated mechanism…
to see More

Credit: UIC / Jenny Fontaine

A new study by researchers at the University of Illinois at Chicago shows that higher estrogen levels make alcohol more beneficial to female mice.

This study Journal of NeuroscienceSuggests that treatment of alcohol use disorders or abuse may be more effective when considering gender differences.

Amy Lassek, an associate professor of psychiatry, anatomy, and cell biology, led a study that specifically looked at estrogen receptors in the brain to determine the mechanism by which estrogen regulates alcohol sensitivity.

In one experiment, researchers analyzed postmortem brain tissue samples from female mice in two reproductive cycle phases. One is characterized by high estrogen levels and the other is characterized by low estrogen levels. They activated estrogen receptors and tracked how dopamine neurons responded to alcohol.

“We found that when one estrogen receptor was activated, the alpha receptor, dopamine neurons, responded to alcohol and had a faster rate of firing,” said the UIC’s Alcohol Research Center (Epigenetics). Says Lasek. “The effect was also greater in tissues taken from high estrogen mice.”

Lasek says that this increased neural activity may lead to greater pleasure when drinking.

“This enhanced feeling of reward may be more likely for alcohol abuse, especially binge drinking behavior,” Lasek said.

In another experiment, researchers blocked estrogen receptors in the ventral tegmental area of ​​the brain-a region that contains dopamine neurons and is known to be associated with drug use-present We have tracked the behavior of both female and male mice under alcohol.

They found that reducing the number of estrogen receptors, such as estrogen receptor alpha, led to reduced drinking behavior, but only in female mice.

“This is a new finding suggesting that there may be a sex-specific role of estrogen receptors in the ventral tegmental area for alcohol use,” Lasek said.

“By learning more about the role of estrogens in brain sensitization to the effects of alcohol, we can develop more personalized therapies for alcohol use disorders and educate women better about how drinking affects them differently. May be able to provide different stages of the reproductive cycle.

“This is especially important because more men are diagnosed with alcohol use disorders, but about 5.3 million women in the United States also suffer from alcohol use disorders,” Lasek said. “There is evidence that women are rapidly transitioning from problematic drinking to alcohol use disorders and suffering from the adverse health effects of alcohol such as increased cancer risk, liver damage, heart disease, and brain damage.”


This research is supported by funding from the National Institute on Alcohol Abuse and Alcoholism (P50AA022538, U01 AA020912), the National Institute on Drug Abuse (R01DA033429), and the National Center for Translational Sciences (UL1TR002003) it was done.

The UIC co-authors of this study are Bertha Vandegrift, Elisa Hilderbrand, Rosalba Satta, Rex Tai, Donghong He, Chang You, Hu Chen, Pingwen Xu, Cassandre Coles and Mark Brodie.

Disclaimer: AAAS and EurekAlert! We are not responsible for the accuracy of news releases posted on EurekAlert. Donate to an institution or use the information through the EurekAlert system.


What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

Pictures Credit


to request, modification Contact us at Here or [email protected]