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Princeton researchers discover “Poison Arrow” antibiotics that resist immunity


Researchers at Princeton University have discovered a new compound that can destroy bacteria while at the same time acting like a “poison arrow” antibiotic that is not affected by antibiotic resistance. The compound SCH-79797 has the ability to penetrate the bacterial wall while destroying cellular folate.

Bacterial infection Investigation Classified as Gram-positive and Gram-negative with an outer layer of armor that eliminates most antibiotics. “This is the first antibiotic that can target non-resistant Gram-positive and Gram-negative bacteria,” said Zemer Gitai, a professor of biology at Edwin Grant Conklin at the university.

As scientists, what they are most excited about is discovering something new about the action of antibiotics-“attacks via two different mechanisms in one molecule-generalizable and Hoping to lead to better antibiotics, antibiotics-the future.”

In general, the greatest weakness of antibiotics is the ability of bacteria to evolve and quickly resist medicine. The team named the derivative of the compound “iresistin” and was unable to produce any form of resistance to SCH-79797.

Dr. James Martin Antibiotics are immune to resistance and safe for humans, while antibiotics are effective against illness, so graduates who worked with the compound were able to Was to convince the lab that it was true.” This is better than rubbing alcohol or bleach, which is deadly for bacteria and human cells.

However, Antibiotics Research means that the team will include allowing the bacteria to propagate multiple generations of compounds and reverse engineer the molecule until it evolves into a resistant state. No need to reverse engineer because the new compound is attractive. In an attempt to prove that the compound is actually very attractive and to understand how it works, Martin has evolved bacteria from multiple antibiotic doses to find out how to cause exposure to resistant strains. Tried some way Gonorrhea..

“Poison arrow”

After years of lack of resistance to antibiotics, the team eventually discovered that a single molecule had two different mechanisms, such as a “poisoned arrow.” Benjamin Bratton is a researcher in molecular biology, Lewis Sigra Institute for Integrated Genomics “The arrow must be sharp to contain the poison, but the poison must kill itself,” he said.

Arrows penetrate thick armor, or the outer membrane of Gram-negative bacteria, and poison the folate, DNA and RNA building blocks-two mechanisms that function synergistically. Bratton explains it as follows: “If you only take two halves of them-there are over-the-counter drugs that can attack either of these two pathways and just throw them in the same pot. And they can’t kill as effectively as our molecules, they are bound together in the same body.”

Also read: Scientists develop artificial red blood cells that mimic natural red blood cells with additional capabilities

Antibiotic development

One problem with their experiment is that the original antibiotic killed both human and bacterial cells at the same level. However, the Irresistin-16 derivative fixed that problem. Promising antibiotics have been shown to be nearly 1000 times more potent than human cells against bacterial cells and cure 16 gonorrhea-infected mice.

According to Stanford Professor KC Huang, a bioengineer in microbiology and immunology who has not participated in new research. That made this work so exciting. The dual mechanism of the poison arrow can revolutionize the development of antibiotics. “Such studies say we can go back and reconsider what we thought were the limits to the development of new antibiotics,” Huang said.

Also read: “Forever” chemicals in drinking water found to cause early menopause, cancer, and other health problems: research

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