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SARS-CoV-2 Omicron variant promotes systems science and precision medicine

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The omicron (B.1.1.529) variant of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was detected in South Africa in November 2021. The World Health Organization (WHO) has declared Omicron as a variant of concern (VOC). Two days after being reported by the South African Genome Monitoring Network.

The mutant was found to be highly contagious and infectious, invade the body’s natural defense mechanisms, be less responsive to vaccines, and be highly mutated. Fifty new mutations were detected, 30 of which were found in peplomer.

study: SARS-CoV-2 Omicron Variant: The Next Stage of the COVID-19 Pandemic and a Call to Weapons for Systems Science and Precision Medicine.. Image Credit: Fit Ztudio / Shutterstock


By January 2022, Omicron had spread to more than 145 countries and the infection rate doubled in a few days. This was a serious concern in Europe and declared an emergency in the United Kingdom.

the study

Recent articles published in MedComm, With the aim of explaining the emergence of the Omicron variant, its structure, its impact on health and medical systems, and the potential challenges of this variant, various predictions by experts on this VOC and coronavirus disease management strategy are made. Presented 2019 (COVID-19) Infections caused by this variant.

The current review required a comparison between the delta variant and the omicron variant, which was established to be more contagious than the omicron variant. The latter is more infectious and contagious. The Omicron variant showed 15 mutations in the receptor binding domain (RBD), while the Delta mutant showed only 2 mutations. These mutations are said to increase infectivity, infectivity, treatment and vaccine resistance to Omicron variants. It currently accounts for almost 90% of all COVID-19 infections worldwide.

Survey results

Cryogenic electron microscopy (Cryo-EM) analysis of human angiotensin converting enzyme 2 (ACE2) complexed with the peaplomer of the SARS-CoV-2 Omicron variant found Omicron affinity. rice field. Peplomers to human ACE2 are similar to delta mutants. Neutralization assays showed increased antibody evasion in the Omicron mutant, but in beta and delta mutants, population-wide epidemiological studies did not reveal antigenic escape.

Recent reports suggest that changes in the active and blocking sites of the Omicron mutant reduce the effectiveness of the COVID-19 vaccine against the virus. It was reportedly found that the spike fusion of the Omicron mutant was impaired. This reduces the formation of synsites and the replication of transfected cells in the lung. However, the involvement of other organs or organ systems remains unknown.

Scientists state that mutations make Omicron variants partially resistant to innate immunity, monoclonal antibodies, and vaccines. Neutralizing antibody.. Evidence suggests changes in human innate and vaccine-induced immunity to Omicron mutants.

The most important management of infected patients is diagnosis by the polymerase chain reaction (PCR) and the antigen COVID-19 test. These are due to the effective detection of Omicron variants in association with the S protein. Nevertheless, these methods are time consuming and costly.Alternatively, use nanoparticles to separate RNA or DNA from the sample via Magnetic fields are useful for quick diagnosis. The nano-capable SARS-CoV-2 sensor selectively detects virus concentrations even at low levels (picomolar levels).

Other efficient biomarkers for the selective detection of SARS-CoV-2, such as segment-selective DNA / RNA, antibodies, and CIRSR / Cas, are being investigated. The biosensing systems supported by these nanotechnology must be epidemiologically validated and verified before being used in clinical and point-of-care (POC) testing.

These biosensors have been speculated to be theoretically effective because they act on peplomers, but have not yet been tested against Omicron variants. Due to the large number of mutations in the peplomer of the Omicron variant, well-designed and highly validated diagnostic tools are needed to detect and confirm this variant in large populations.

The biosensing approach and artificial intelligence (AI) supported by the Medical Internet (IoMT) use information about viral load to understand disease progression and assess therapeutic effectiveness.These can be used and can be used as part of the detection of Omicron variants. Telemedicine To analyze the health effects with reference to an individual’s medical conditioning / profiling. Therefore, individual monitoring of the infection progression of the Omicron mutant can be performed.

To prevent virus infection and infection, proper hygiene must be maintained and protective equipment and masks must be used. In addition, you must strictly follow physical distance, heavy testing, restricted travel, patient tracking, and running test campaigns at home. Special care should be taken when monitoring high-risk populations. A ready-to-market interdisciplinary approach to bedside or point of care (POC) platforms may help in the proper management of Omicron variants.

More effective diagnostic tools and treatments should be developed through personalized / precise medical care. Booster immunization after complete vaccination has proven effective against COVID-19 infection. Nanotechnology can be used to optimize treatment through developed therapies and vaccines. Since SARS-CoV-2 infection can affect a variety of organs, there is an urgent need to investigate treatments. Infection-related side effects analyzed, and post-infection recovery of monitored patients – to achieve new pharmacologically relevant therapeutic involvement in all aspects of nanomedicine.

There is an urgent need to design available vaccines that can be delivered to the target site through a nanomedical approach. Other treatments can be used with nanomedicine to control post-infection outcomes. Dietary supplements are a good choice. As precision medicine, we can optimize dietary supplements and nanomedicines prescribed by artificial vaccines. It can also be prescribed as personalized medicine depending on the patient’s health profile.

Artificial intelligence (AI), big data reservoirs, subtype science, and bioinformatics systems are formidable arsenals that lead to more specific treatments and better patient outcomes.

Discussion and conclusions

According to health experts, countering this third wave of the COVID-19 pandemic requires an interdisciplinary approach, including a better understanding of the infections caused by the major Omicron variants. AI can be used to design and monitor new therapies Effectiveness of Drug and disease management strategies; to raise awareness about vaccination, especially booster immune programs. Use a biomedical / biotechnology-based approach focused on developing better test systems. For gene sequencing and more effective treatment; to ensure a better public-private partnership for a socio-economic balance of health and regulation.

Attention should be paid to the evolution, infection, course and prognosis of the virus to combat COVID-19 and future pandemics, but the epidemiology and vaccination of the disease should not be underestimated.

Sources

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2/ https://www.news-medical.net/news/20220221/SARS-CoV-2-Omicron-variant-prompts-system-sciences-and-precision-medicine.aspx

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