NEW YORK/LONDON (Reuters)-A leading study found that hydroxychloroquine increases the risk of death in COVID-19 patients, in addition to the confusion over malaria drugs advocated by President Donald U.S. It was withdrawn one week after Trump.
The Lancet Medical Journal discontinued the study because of concerns about the quality and authenticity of its data after three authors withdrew it. The World Health Organization (WHO) will suspend them as a result of the study and then resume the hydroxychloroquine test. Dozens of other trials have been restarted or are in progress.
The three authors said that the company that provided the data, Surgisphere, would not transfer the data set for independent review, and they “can no longer guarantee the authenticity of the major data sources.”
Dr. Sapan Desai, CEO of Surgisphere, the fourth author of the study, declined to comment on the withdrawal.
“We take the issue of scientific integrity very seriously,” Lancet added, “and there are many open questions about the questionable data and data that were allegedly included in this study. ]he added.
Another study in the New England Journal of Medicine (NEJM), using Surgisphere data and sharing the same lead author, Mandeep Mehra, Harvard Medical School Professor, was withdrawn for the same reason.
Lancet said there is an urgent need for a review of Surgisphere’s research collaboration.
The competition to understand and treat the new coronaviruses causing the COVID-19 pandemic accelerates the pace of research, and peer-reviewed scientific journals provide reliable information to doctors, policy makers, and the general public. Source.
“Two of the most prestigious medical journals in the world,” said Lancet and NEJM, who are professors of psychology and experts at the UK Open Science Center, said I said that should be investigated as to what was obtained and editorial check.
“Failure to resolve such fundamental concerns about the data,” he said, “serious questions about standards of editing,” raises the peer review process, he said.
Lancet did not immediately respond to Reuters’ request for comment. No comments from NEJM were obtained.
The observational study, published May 22 at The Lancet, included 96,000 hospitalized COVID-19 patients, some said they were treated with malarial drugs decades ago. It argued that people treated with hydroxychloroquine or related chloroquines were at a higher risk of death and heart rhythm problems than unmedicated patients.
“We didn’t do enough to ensure that the data source was adequate for this use,” said the study’s lead author, Mehra, in a statement. “So, and for all the confusion-either directly or indirectly-I’m really sorry.”
Many scientists have expressed concern about the study. This study was already fixed last week due to incorrect location data. Nearly 150 doctors signed an open letter to The Lancet, questioned the conclusions of this article, and asked them to publish peer-reviewed comments before publication.
Stephen Evans, a professor of pharmacoepidemiology at the London Health University, said the decision to withdraw was “right,” but did not answer the question about whether hydroxychloroquine is effective for COVID-19.
“It’s still true that the results of randomized trials are needed to draw reliable conclusions,” he said.
Report by Michael Erman, Peter Henderson, Kate Kelland, Josephine Mason. Edited by Leslie Adler, Tom Brown, Giles Elgood, Carmel Crimmins
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